Effect of imidazole antifungals on the development of germ tubes by strains of Candida albicans

E. M. Johnson, M. D. Richardson, D. W. Warnock

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Three imidazole antifungals (ketoconazole, tioconazole and miconazole) were examined for their effect on germ tube development by synchronous blastospore populations and on actively growing germ tubes of three strains of Candida albicans. After incubation in serum for 4 h the largest differences in germ tube elongation between strains were detected at concentrations (0.005 mg/l) where minimal inhibition was observed. Germ tube elongation in antifungal-containing serum diminished with increasing concentration. Maximum inhibition occurred at concentrations of 0.5 mg/l. All three antifungals inhibited the rate of hyphal elongation by the strains over a 6 h period at this concentration. Tests where germinated blastospores of strain 3281 were transferred to serum containing 00.5 mg/l of antifungal indicated that all three drugs inhibited further elongation. However, the rate of inhibition was dependent upon the length of time germination had preceeded in serum alone prior to transfer to antifungal-containing serum.
    Original languageEnglish
    Pages (from-to)303-316
    Number of pages13
    JournalJournal of Antimicrobial Chemotherapy
    Volume12
    Issue number4
    Publication statusPublished - 1983

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