Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

Artur Pałasz; Marcelina Pałka; Łukasz Filipczyk; Itiana Castro Menezes; Ewa Rojczyk; John J. Worthington; Aneta Piwowarczyk-Nowak; Marek Krzystanek; Ryszard Wiaderkiewicz

doi:10.1007/s00702-018-1868-2

Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

Artur Pałasz^*, Marcelina Pałka, Łukasz Filipczyk, Itiana Castro Menezes, Ewa Rojczyk, John J. Worthington, Aneta Piwowarczyk-Nowak, Marek Krzystanek, Ryszard Wiaderkiewicz

^*Corresponding author for this work

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics influence the peptidergic circuits in the amygdala remains unclear. This study specifies the impact profile of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantification via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating effects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses.

Original language	English
Pages (from-to)	1099-1105
Number of pages	7
Journal	Journal of Neural transmission
Volume	125
Issue number	7
Early online date	27 Feb 2018
DOIs	https://doi.org/10.1007/s00702-018-1868-2
Publication status	Published - 1 Jul 2018

Keywords

Amygdala
Chlorpromazine
Haloperidol
Kisspeptin
POMC
Spexin

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10.1007/s00702-018-1868-2

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Pałasz, A., Pałka, M., Filipczyk, Ł., Menezes, I. C., Rojczyk, E., Worthington, J. J., Piwowarczyk-Nowak, A., Krzystanek, M., & Wiaderkiewicz, R. (2018). Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala. Journal of Neural transmission, 125(7), 1099-1105. https://doi.org/10.1007/s00702-018-1868-2

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abstract = "Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics influence the peptidergic circuits in the amygdala remains unclear. This study specifies the impact profile of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantification via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating effects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses.",

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Pałasz, A, Pałka, M, Filipczyk, Ł, Menezes, IC, Rojczyk, E, Worthington, JJ, Piwowarczyk-Nowak, A, Krzystanek, M & Wiaderkiewicz, R 2018, 'Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala', Journal of Neural transmission, vol. 125, no. 7, pp. 1099-1105. https://doi.org/10.1007/s00702-018-1868-2

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AU - Pałka, Marcelina

AU - Filipczyk, Łukasz

AU - Menezes, Itiana Castro

AU - Rojczyk, Ewa

AU - Worthington, John J.

AU - Piwowarczyk-Nowak, Aneta

AU - Krzystanek, Marek

AU - Wiaderkiewicz, Ryszard

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Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

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