Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial

Hunter R. Underhill; Chun Yuan; Xue Qiao Zhao; Larry W. Kraiss; Dennis L. Parker; Tobias Saam; Baocheng Chu; Norihide Takaya; Fei Liu; Nayak L. Polissar; Blazej Neradilek; Joel S. Raichlen; Valerie A. Cain; John C. Waterton; Wendy Hamar; Thomas S. Hatsukami

doi:10.1016/j.ahj.2007.11.018

Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial

Hunter R. Underhill, Chun Yuan, Xue Qiao Zhao, Larry W. Kraiss, Dennis L. Parker, Tobias Saam, Baocheng Chu, Norihide Takaya, Fei Liu, Nayak L. Polissar, Blazej Neradilek, Joel S. Raichlen, Valerie A. Cain, John C. Waterton, Wendy Hamar, Thomas S. Hatsukami

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition. Methods: The randomized, double-blind ORION trial used 1.5-T MRI to image carotid atherosclerotic plaques at baseline and after 24 months of treatment. Forty-three patients with fasting low-density lipoprotein cholesterol ≥100 and

Original language	English
Pages (from-to)	584-e8
Journal	American Heart Journal
Volume	155
Issue number	3
DOIs	https://doi.org/10.1016/j.ahj.2007.11.018
Publication status	Published - Mar 2008

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10.1016/j.ahj.2007.11.018

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Underhill, H. R., Yuan, C., Zhao, X. Q., Kraiss, L. W., Parker, D. L., Saam, T., Chu, B., Takaya, N., Liu, F., Polissar, N. L., Neradilek, B., Raichlen, J. S., Cain, V. A., Waterton, J. C., Hamar, W., & Hatsukami, T. S. (2008). Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial. American Heart Journal, 155(3), 584-e8. https://doi.org/10.1016/j.ahj.2007.11.018

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title = "Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial",

abstract = "Background: Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition. Methods: The randomized, double-blind ORION trial used 1.5-T MRI to image carotid atherosclerotic plaques at baseline and after 24 months of treatment. Forty-three patients with fasting low-density lipoprotein cholesterol ≥100 and",

author = "Underhill, {Hunter R.} and Chun Yuan and Zhao, {Xue Qiao} and Kraiss, {Larry W.} and Parker, {Dennis L.} and Tobias Saam and Baocheng Chu and Norihide Takaya and Fei Liu and Polissar, {Nayak L.} and Blazej Neradilek and Raichlen, {Joel S.} and Cain, {Valerie A.} and Waterton, {John C.} and Wendy Hamar and Hatsukami, {Thomas S.}",

note = "T-32 HL07838, NHLBI NIH HHS, United States",

year = "2008",

month = mar,

doi = "10.1016/j.ahj.2007.11.018",

language = "English",

volume = "155",

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journal = "American Heart Journal",

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Underhill, HR, Yuan, C, Zhao, XQ, Kraiss, LW, Parker, DL, Saam, T, Chu, B, Takaya, N, Liu, F, Polissar, NL, Neradilek, B, Raichlen, JS, Cain, VA, Waterton, JC, Hamar, W & Hatsukami, TS 2008, 'Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial', American Heart Journal, vol. 155, no. 3, pp. 584-e8. https://doi.org/10.1016/j.ahj.2007.11.018

TY - JOUR

T1 - Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial

AU - Underhill, Hunter R.

AU - Yuan, Chun

AU - Zhao, Xue Qiao

AU - Kraiss, Larry W.

AU - Parker, Dennis L.

AU - Saam, Tobias

AU - Chu, Baocheng

AU - Takaya, Norihide

AU - Liu, Fei

AU - Polissar, Nayak L.

AU - Neradilek, Blazej

AU - Raichlen, Joel S.

AU - Cain, Valerie A.

AU - Waterton, John C.

AU - Hamar, Wendy

AU - Hatsukami, Thomas S.

N1 - T-32 HL07838, NHLBI NIH HHS, United States

PY - 2008/3

Y1 - 2008/3

N2 - Background: Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition. Methods: The randomized, double-blind ORION trial used 1.5-T MRI to image carotid atherosclerotic plaques at baseline and after 24 months of treatment. Forty-three patients with fasting low-density lipoprotein cholesterol ≥100 and

AB - Background: Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition. Methods: The randomized, double-blind ORION trial used 1.5-T MRI to image carotid atherosclerotic plaques at baseline and after 24 months of treatment. Forty-three patients with fasting low-density lipoprotein cholesterol ≥100 and

U2 - 10.1016/j.ahj.2007.11.018

DO - 10.1016/j.ahj.2007.11.018

M3 - Article

C2 - 18294500

SN - 0002-8703

VL - 155

SP - 584-e8

JO - American Heart Journal

JF - American Heart Journal

IS - 3

ER -

Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: A high-resolution magnetic resonance imaging trial

Abstract

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