Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart

Joanne L. Slater-Jefferies; Samuel P. Hoile; Karen A. Lillycrop; Paul A. Townsend; Mark A. Hanson; Graham C. Burdge

doi:10.1016/j.plefa.2010.07.006

Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart

Joanne L. Slater-Jefferies, Samuel P. Hoile, Karen A. Lillycrop, Paul A. Townsend, Mark A. Hanson, Graham C. Burdge

Research output: Contribution to journal › Article › peer-review

Abstract

Variations in the fatty acid composition of lipids in the heart alter its function and susceptibility to ischaemic injury. We investigated the effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Rats were fed either 40 or 100 g/kg fat (9:1 lard:soybean oil) from weaning until day 105. There were significant interactive effects of sex and fat intake on the proportions of fatty acids in heart phospholipids, dependent on phospholipid classes. 20:4n-6, but not 22:6n-3, was higher in phospholipids in females than males fed a low, but not a high, fat diet. There was no effect of sex on the composition of triacylglycerol. These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease. © 2010 Elsevier Ltd.

Original language	English
Pages (from-to)	219-223
Number of pages	4
Journal	Prostaglandins, Leukotrienes & Essential Fatty Acids
Volume	83
Issue number	4-6
DOIs	https://doi.org/10.1016/j.plefa.2010.07.006
Publication status	Published - Oct 2010

Keywords

Fatty acids
Heart
Phophospholipids
Rat
Sex
Triacylglycerol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.plefa.2010.07.006

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title = "Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart",

abstract = "Variations in the fatty acid composition of lipids in the heart alter its function and susceptibility to ischaemic injury. We investigated the effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Rats were fed either 40 or 100 g/kg fat (9:1 lard:soybean oil) from weaning until day 105. There were significant interactive effects of sex and fat intake on the proportions of fatty acids in heart phospholipids, dependent on phospholipid classes. 20:4n-6, but not 22:6n-3, was higher in phospholipids in females than males fed a low, but not a high, fat diet. There was no effect of sex on the composition of triacylglycerol. These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease. {\textcopyright} 2010 Elsevier Ltd.",

keywords = "Fatty acids, Heart, Phophospholipids, Rat, Sex, Triacylglycerol",

author = "Slater-Jefferies, {Joanne L.} and Hoile, {Samuel P.} and Lillycrop, {Karen A.} and Townsend, {Paul A.} and Hanson, {Mark A.} and Burdge, {Graham C.}",

year = "2010",

month = oct,

doi = "10.1016/j.plefa.2010.07.006",

language = "English",

volume = "83",

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T1 - Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart

AU - Slater-Jefferies, Joanne L.

AU - Hoile, Samuel P.

AU - Lillycrop, Karen A.

AU - Townsend, Paul A.

AU - Hanson, Mark A.

AU - Burdge, Graham C.

PY - 2010/10

Y1 - 2010/10

N2 - Variations in the fatty acid composition of lipids in the heart alter its function and susceptibility to ischaemic injury. We investigated the effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Rats were fed either 40 or 100 g/kg fat (9:1 lard:soybean oil) from weaning until day 105. There were significant interactive effects of sex and fat intake on the proportions of fatty acids in heart phospholipids, dependent on phospholipid classes. 20:4n-6, but not 22:6n-3, was higher in phospholipids in females than males fed a low, but not a high, fat diet. There was no effect of sex on the composition of triacylglycerol. These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease. © 2010 Elsevier Ltd.

AB - Variations in the fatty acid composition of lipids in the heart alter its function and susceptibility to ischaemic injury. We investigated the effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart. Rats were fed either 40 or 100 g/kg fat (9:1 lard:soybean oil) from weaning until day 105. There were significant interactive effects of sex and fat intake on the proportions of fatty acids in heart phospholipids, dependent on phospholipid classes. 20:4n-6, but not 22:6n-3, was higher in phospholipids in females than males fed a low, but not a high, fat diet. There was no effect of sex on the composition of triacylglycerol. These findings suggest that sex is an important factor in determining the incorporation of dietary fatty acids into cardiac lipids. This may have implications for sex differences in susceptibility to heart disease. © 2010 Elsevier Ltd.

KW - Fatty acids

KW - Heart

KW - Phophospholipids

KW - Rat

KW - Sex

KW - Triacylglycerol

U2 - 10.1016/j.plefa.2010.07.006

DO - 10.1016/j.plefa.2010.07.006

M3 - Article

C2 - 20719489

SN - 0952-3278

VL - 83

SP - 219

EP - 223

JO - Prostaglandins, Leukotrienes & Essential Fatty Acids

JF - Prostaglandins, Leukotrienes & Essential Fatty Acids

IS - 4-6

ER -

Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart

Abstract

Keywords

UN SDGs

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