Effect of temperature on the volume and compressibilities of some amphiphilic penicillins in aqueous solution

Pablo Taboada, Manuel Gutiérrez-Pichel, Silvia Barbosa, David Attwood, Victor Mosquera

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Apparent molal volumes and adiabatic compressibilities of aqueous solutions of the amphiphilic anionic penicillins sodium cloxacillin and sodium dicloxacillin have been determined from density and ultrasound velocity measurements in the temperature range 288.15-313.15 K. Critical concentrations for aggregation of these drugs were obtained from both techniques. Positive deviation from the Debye-Hückel limiting law of the apparent molal volume of both drugs at temperatures higher than 298.15 K provides evidence of pre-association at concentrations below the critical concentration. Apparent molal adiabatic compressibilities of the aggregates formed by the drugs, calculated by combining the ultrasound velocity and density data, were typical of those for a stacked aggregate.
    Original languageEnglish
    Pages (from-to)703-709
    Number of pages6
    JournalPhysical Chemistry Chemical Physics
    Volume5
    Issue number4
    DOIs
    Publication statusPublished - 15 Feb 2003

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