Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction

Joanna L. Stanley; Irene J. Andersson; Cassandra J. Hirt; Linn Moore; Mark R. Dilworth; Alejandro R. Chade; Colin P. Sibley; Sandra T. Davidge; Philip N. Baker

doi:10.1095/biolreprod.111.096198

Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction

Joanna L. Stanley, Irene J. Andersson, Cassandra J. Hirt, Linn Moore, Mark R. Dilworth, Alejandro R. Chade, Colin P. Sibley, Sandra T. Davidge, Philip N. Baker

Research output: Contribution to journal › Article › peer-review

Abstract

Fetal growth restriction (FGR) greatly increases the risk of perinatal morbidity and mortality and is associated with increased uterine artery resistance and levels of oxidative stress. There are currently no available treatments for this condition. The hypothesis that the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol) would improve uterine artery function and rescue fetal growth was tested in a mouse model of FGR, using the endothelial nitric oxide synthase knockout mouse (Nos3-/-). Pregnant Nos3-/- and control C57BL/6J mice were treated with the superoxide dismutase-mimetic Tempol (1 mmol/L) or vehicle from Gestational Day 12.5 to 18.5. Tempol treatment significantly increased pup weight (P

Original language	English
Pages (from-to)	25
Journal	Biology of reproduction
Volume	87
Issue number	1
DOIs	https://doi.org/10.1095/biolreprod.111.096198
Publication status	Published - Jul 2012

Keywords

Intrauterine growth restriction
Nitric oxide
Oxidative stress
Placental transport
Pregnancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1095/biolreprod.111.096198

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title = "Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction",

abstract = "Fetal growth restriction (FGR) greatly increases the risk of perinatal morbidity and mortality and is associated with increased uterine artery resistance and levels of oxidative stress. There are currently no available treatments for this condition. The hypothesis that the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol) would improve uterine artery function and rescue fetal growth was tested in a mouse model of FGR, using the endothelial nitric oxide synthase knockout mouse (Nos3-/-). Pregnant Nos3-/- and control C57BL/6J mice were treated with the superoxide dismutase-mimetic Tempol (1 mmol/L) or vehicle from Gestational Day 12.5 to 18.5. Tempol treatment significantly increased pup weight (P",

keywords = "Intrauterine growth restriction, Nitric oxide, Oxidative stress, Placental transport, Pregnancy",

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note = "Stanley, Joanna L Andersson, Irene J Hirt, Cassandra J Moore, Linn Dilworth, Mark R Chade, Alejandro R Sibley, Colin P Davidge, Sandra T Baker, Philip N HL095638/HL/NHLBI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Biology of reproduction Biol Reprod. 2012 Jul 26;87(1):25, 1-8. Print 2012 Jul.",

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language = "English",

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AU - Stanley, Joanna L.

AU - Andersson, Irene J.

AU - Hirt, Cassandra J.

AU - Moore, Linn

AU - Dilworth, Mark R.

AU - Chade, Alejandro R.

AU - Sibley, Colin P.

AU - Davidge, Sandra T.

AU - Baker, Philip N.

N1 - Stanley, Joanna L Andersson, Irene J Hirt, Cassandra J Moore, Linn Dilworth, Mark R Chade, Alejandro R Sibley, Colin P Davidge, Sandra T Baker, Philip N HL095638/HL/NHLBI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Biology of reproduction Biol Reprod. 2012 Jul 26;87(1):25, 1-8. Print 2012 Jul.

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KW - Intrauterine growth restriction

KW - Nitric oxide

KW - Oxidative stress

KW - Placental transport

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Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction

Abstract

Keywords

UN SDGs

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