Effect of thermal cycling on the properties of thermoresponsive poly(N-isopropylacrylamide) hydrogels

Sai Kit Li, Antony D'Emanuele

    Research output: Contribution to journalArticlepeer-review


    Crosslinked poly(N-isopropylacrylamide) hydrogels have been widely studied for a variety of thermoresponsive applications, including chromatography, affinity precipitation, controlled biocatalysis, viable cell immobilisation, biomimetic actuators and, in particular, modulated drug delivery. The exploitation of crosslinked poly(N-isopropylacrylamide) hydrogels in all these applications relies on the well-known temperature-sensitive swelling properties of these hydrogels. The purpose of the current study was to determine the effects of repeated thermal cycling on the thermoresponsive swelling behaviour of crosslinked poly(N-isopropylacrylamide) hydrogels. The results show that repeated thermal cycling leads to the formation of cracks on the surface of the hydrogels. Repeated thermal cycling also results in a decreased degree of swelling in the crosslinked poly(N-isopropylacrylamide) hydrogels at temperatures below the volume phase transition temperature (VPTT). © 2003 Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)27-34
    Number of pages7
    JournalInternational Journal of Pharmaceutics
    Issue number1-2
    Publication statusPublished - 28 Nov 2003


    • Effect of thermal cycling
    • Hydrogels
    • Poly(N-isopropylacrylamide)
    • Responsive drug delivery
    • Thermoresponsive polymers


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