Effects of a phosphodiesterase-5 (PDE5) inhibitor on endothelium-dependent relaxation of myometrial small arteries

Mark Wareing, Jenny E. Myers, Maureen O'Hara, Louise C. Kenny, Averil Y. Warren, Michael J. Taggart, Laurence Skillern, Ian Machin, Philip N. Baker

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: In preeclampsia, endothelium-dependent function is markedly aberrant. Myometrial resistance arteries from women with preeclampsia show a minimal, wholly nitric oxide-mediated, bradykinin-induced relaxation. Our aim was to test that phosphodiesterase 5 (PDE5) inhibition could improve endothelium-dependent function in preeclampsia. Study design: Small arteries dissected from myometrial biopsies obtained at cesarean section from normal pregnant women (N = 22) or women with preeclampsia (N = 24) were mounted on wire or pressure myographs. Vessels were constricted (arginine vasopressin or U46619) and relaxed (bradykinin) before and after incubation with a PDE5 inhibitor, UK-343664. Results: Endothelium-dependent vasodilatation was decreased in vessels from women with preeclampsia. 100 nmol/L UK-343664 did not affect normal pregnant but significantly improved relaxation of the vessels from women with preeclampsia. Conclusion: A PDE5 inhibitor enhances endothelial function of myometrial vessels from women with preeclampsia, such that the behavior of these arteries approximates to those from normal women. These agents offer a potential therapeutic strategy for the management of preeclampsia. © 2004 Elsevier Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)1283-1290
    Number of pages7
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume190
    Issue number5
    DOIs
    Publication statusPublished - May 2004

    Keywords

    • Endothelium-dependent relaxation
    • Myometrial small arteries
    • Phosphodiesterase inhibitor
    • Preeclampsia

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