Effects of benoxinate hydrochloride 0.4% on the morphological appearance of the cornea using confocal microscopy

Inma Perez-Gomez, Jo Hollingsworth, Nathan Efron

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Purpose: To investigate whether benoxinate hydrochloride 0.4% used to make confocal microscopy more comfortable alters the morphology of the cornea as viewed with the confocal microscope. Methods: Confocal microscopy was performed on both eyes of 10 subjects prior to instillation of either topical anaesthetic or non-preserved sterile saline, on two randomly ordered occasions. Images of all corneal layers were analysed quantitatively and qualitatively in a masked fashion. Results: The images were similar in appearance in 5/10 subjects, there was greater clarity when anaesthetic was instilled in 4/10 subjects, and in the remaining subject there was greater clarity when saline was used. Anaesthetic had no influence on anterior keratocyte density (AKD), posterior keratocyte density (PKD) or endothelial cell density (ECD). Conclusions: Local anaesthetic does not affect corneal morphology as imaged using the confocal microscope. However, failure to use anaesthetic may lead to a degradation of image quality due to patient discomfort and excessive eye movements. © 2003 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)45-48
    Number of pages3
    JournalContact Lens and Anterior Eye
    Volume27
    Issue number1
    DOIs
    Publication statusPublished - Mar 2004

    Keywords

    • Anaesthesia
    • Confocal microscopy
    • Endothelial cell density
    • Keratocyte density

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