Effects of Desensitisers on Adhesive–dentin Bonding Strength: A Systematic Review and Meta-analysis

Jiarui Li, Fang Hua, Hongye Yang, Cui Huang

Research output: Contribution to journalArticlepeer-review


Purpose: This study aimed to systematically review in vitro studies that evaluated adhesive–dentin bond strength with or without the addition of desensitisers.
Materials and methods: A search was conducted in four databases (i.e. PubMed, Embase, Web of Science and Cochrane Library) without publication date or language limits in accordance with the Preferred Reporting Items for Systematic Reviews. Two reviewers selected the studies, extracted data and assessed the risk of bias independently. The inclusion criterion was the evaluation of the effect of instant or ageing bond strength after applying desensitiser in the bonding step. The risk of bias was assessed following the method in Sarkis–Onofre’s study. Meta-analysis was conducted using Review Manager 5.3.
Results: A total of 1636 articles were found through our search strategy; 59 articles were selected for full-text analysis, and 32 were systematically reviewed, with 18 considered in meta-analysis. Results showed a significant difference among various kinds of desensitisers. The subgroup comparison showed high heterogeneity among the different kinds of desensitisers. The use of casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) and Arginine-CaCO3 showed no negative effect on the immediate bond strength, whereas other desensitisers showed influence to a certain extent.
Conclusion: Different desensitisers have various effects on microtensile bond strength. Desensitisers may be selected based on the bonding strength and especially used to relieve tooth sensitivity after tooth preparation.
Original languageEnglish
JournalJournal of Adhesive Dentistry
Publication statusAccepted/In press - 1 Aug 2020


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