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Abstract
Background: A EULAR taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). In this paper, we review the literature on the effect of diet on the progression of RMDs.
Methods: We conducted systematic reviews and meta-analyses of studies related to diet and disease outcomes in seven RMDs: osteoarthritis (OA), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), systemic sclerosis (SSc) and gout. In the first phase, we identified existing relevant systematic reviews and meta-analyses, published from 2013-2018. In the second phase, we expanded the review to include published original studies on diet in RMDs, with no restriction on publication date. Systematic reviews / original studies were included if they assessed a dietary exposure in one of the above RMDs, and reported results regarding progression of disease (e.g. pain, function, joint damage).
Results: In total, 24 systematic reviews and 150 original articles were included. Many dietary exposures have been studied (N=83), although the majority of studies addressed people with OA and RA. Most dietary exposures were assessed by relatively few studies. Exposures that have been assessed by multiple, well-conducted studies (e.g. OA: vitamin D, chondroitin, glucosamine; RA: omega-3) were classified as moderate evidence of small effects on disease progression.
Conclusion: The current literature suggests that there is moderate evidence for a small benefit for certain dietary components. High-level evidence of clinically meaningful effect sizes from individual dietary exposures on outcomes in RMDs is missing.
Word count: 244 (max: 250)
Methods: We conducted systematic reviews and meta-analyses of studies related to diet and disease outcomes in seven RMDs: osteoarthritis (OA), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), systemic sclerosis (SSc) and gout. In the first phase, we identified existing relevant systematic reviews and meta-analyses, published from 2013-2018. In the second phase, we expanded the review to include published original studies on diet in RMDs, with no restriction on publication date. Systematic reviews / original studies were included if they assessed a dietary exposure in one of the above RMDs, and reported results regarding progression of disease (e.g. pain, function, joint damage).
Results: In total, 24 systematic reviews and 150 original articles were included. Many dietary exposures have been studied (N=83), although the majority of studies addressed people with OA and RA. Most dietary exposures were assessed by relatively few studies. Exposures that have been assessed by multiple, well-conducted studies (e.g. OA: vitamin D, chondroitin, glucosamine; RA: omega-3) were classified as moderate evidence of small effects on disease progression.
Conclusion: The current literature suggests that there is moderate evidence for a small benefit for certain dietary components. High-level evidence of clinically meaningful effect sizes from individual dietary exposures on outcomes in RMDs is missing.
Word count: 244 (max: 250)
| Original language | English |
|---|---|
| Journal | RMD Open |
| Publication status | Accepted/In press - 1 Apr 2022 |
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Dive into the research topics of 'Effects of diet on the outcomes of rheumatic and musculoskeletal diseases (RMDs): systematic review and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs'. Together they form a unique fingerprint.Projects
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Centre for Epidemiology Versus Arthritis.
Dixon, W. (PI), Bruce, I. (CoI), Felson, D. (CoI), Hyrich, K. (CoI), Lunt, M. (CoI), Mcbeth, J. (CoI), Mcdonagh, J. (CoI), O'Neill, T. (CoI), Sergeant, J. (CoI), Verstappen, S. (CoI) & Serafimova, I. (Support team)
1/08/18 → 31/07/25
Project: Research