Effects of ECT on pituitary hormone release: relationship to seizure, clinical variables and outcome

J F Deakin; I N Ferrier; T J Crow; Eve C. Johnstone; P Lawler

Effects of ECT on pituitary hormone release: relationship to seizure, clinical variables and outcome

J F Deakin, I N Ferrier, T J Crow, Eve C. Johnstone, P Lawler

Division of Neuroscience

MRC Clinical Research Centre, Harrow

Research output: Contribution to journal › Article › peer-review

Abstract

Prolactin, cortisol, growth hormone and TSH serum levels (before and 15 minutes after treatment) were measured in 62 patients with endogenous depression randomly allocated to real or pseudo-ECT. Prolactin increased significantly more in those receiving real ECT than in those receiving pseudo-ECT, but the size of this effect had diminished by the time of the last (8th) treatment in the trial. Cortisol secretion was also significantly increased following the first treatment by real ECT, but this increase was of significantly smaller size in patients with delusions. Tolerance to the effects of ECT on cortisol secretion was not observed. No effects of ECT on growth hormone or TSH secretion were detected, and no clear evidence was obtained that endocrine responses can be used as a predictor of response to ECT.

Original language	English
Pages (from-to)	618-24
Number of pages	7
Journal	The British journal of psychiatry : the journal of mental science
Volume	143
Publication status	Published - Dec 1983

Keywords

Depressive Disorder
Electroconvulsive Therapy
Growth Hormone
Humans
Hydrocortisone
Pituitary Hormones
Prolactin
Thyrotropin
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Cite this

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title = "Effects of ECT on pituitary hormone release: relationship to seizure, clinical variables and outcome",

abstract = "Prolactin, cortisol, growth hormone and TSH serum levels (before and 15 minutes after treatment) were measured in 62 patients with endogenous depression randomly allocated to real or pseudo-ECT. Prolactin increased significantly more in those receiving real ECT than in those receiving pseudo-ECT, but the size of this effect had diminished by the time of the last (8th) treatment in the trial. Cortisol secretion was also significantly increased following the first treatment by real ECT, but this increase was of significantly smaller size in patients with delusions. Tolerance to the effects of ECT on cortisol secretion was not observed. No effects of ECT on growth hormone or TSH secretion were detected, and no clear evidence was obtained that endocrine responses can be used as a predictor of response to ECT.",

keywords = "Depressive Disorder, Electroconvulsive Therapy, Growth Hormone, Humans, Hydrocortisone, Pituitary Hormones, Prolactin, Thyrotropin, Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",

author = "Deakin, {J F} and Ferrier, {I N} and Crow, {T J} and Johnstone, {Eve C.} and P Lawler",

year = "1983",

month = dec,

language = "English",

volume = "143",

pages = "618--24",

journal = "The British journal of psychiatry : the journal of mental science",

issn = "0007-1250",

publisher = "Cambridge University Press",

}

TY - JOUR

T1 - Effects of ECT on pituitary hormone release

T2 - relationship to seizure, clinical variables and outcome

AU - Deakin, J F

AU - Ferrier, I N

AU - Crow, T J

AU - Johnstone, Eve C.

AU - Lawler, P

PY - 1983/12

Y1 - 1983/12

N2 - Prolactin, cortisol, growth hormone and TSH serum levels (before and 15 minutes after treatment) were measured in 62 patients with endogenous depression randomly allocated to real or pseudo-ECT. Prolactin increased significantly more in those receiving real ECT than in those receiving pseudo-ECT, but the size of this effect had diminished by the time of the last (8th) treatment in the trial. Cortisol secretion was also significantly increased following the first treatment by real ECT, but this increase was of significantly smaller size in patients with delusions. Tolerance to the effects of ECT on cortisol secretion was not observed. No effects of ECT on growth hormone or TSH secretion were detected, and no clear evidence was obtained that endocrine responses can be used as a predictor of response to ECT.

AB - Prolactin, cortisol, growth hormone and TSH serum levels (before and 15 minutes after treatment) were measured in 62 patients with endogenous depression randomly allocated to real or pseudo-ECT. Prolactin increased significantly more in those receiving real ECT than in those receiving pseudo-ECT, but the size of this effect had diminished by the time of the last (8th) treatment in the trial. Cortisol secretion was also significantly increased following the first treatment by real ECT, but this increase was of significantly smaller size in patients with delusions. Tolerance to the effects of ECT on cortisol secretion was not observed. No effects of ECT on growth hormone or TSH secretion were detected, and no clear evidence was obtained that endocrine responses can be used as a predictor of response to ECT.

KW - Depressive Disorder

KW - Electroconvulsive Therapy

KW - Growth Hormone

KW - Humans

KW - Hydrocortisone

KW - Pituitary Hormones

KW - Prolactin

KW - Thyrotropin

KW - Clinical Trial

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

M3 - Article

C2 - 6661605

SN - 0007-1250

VL - 143

SP - 618

EP - 624

JO - The British journal of psychiatry : the journal of mental science

JF - The British journal of psychiatry : the journal of mental science

ER -

Effects of ECT on pituitary hormone release: relationship to seizure, clinical variables and outcome

Abstract

Keywords

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