Effects of gentamicin, neomycin and tobramycin on renal calcium and magnesium handling in two rats strains

H. O. Garland, T. J. Birdsey, C. G. Davidge, J. T. McLaughlin, L. M. Oakes, A. J. Smith, E. S. Harpur

    Research output: Contribution to journalArticlepeer-review

    Abstract

    1. Standard renal clearance techniques were used to compare the acute effects of gentamicin, neomycin and tobramycin on renal calcium and magnesium handling in Sprague-Dawley and Fischer 344 rats. 2. Significant hypercalciuric and hypermagnesiuric responses to all three drugs (P <0.01) were apparent within 30 min of the onset of drug infusion. 3. The magnitude of the acute hypercalciuric and hypermagnesiuric response to the three aminoglycosides was comparable. This contrasts with their nephrotoxic action where neomycin > > gentamicin > tobramycin. The magnitude of the acute physiological responses to these drugs do not therefore reflect their nephrotoxic potential. 4. Sprague-Dawley rats were at least as responsive as Fischer rats in their acute renal responses to gentamicin. If Fischer rats are more sensitive to aminoglycoside nephrotoxicity than Sprague-Dawley rats, this is not reflected in their acute responses to gentamicin.
    Original languageEnglish
    Pages (from-to)109-115
    Number of pages6
    JournalClinical and Experimental Pharmacology and Physiology
    Volume21
    Issue number2
    Publication statusPublished - 1994

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