TY - JOUR
T1 - Effects of Hypoxia during Continuous and Intermittent Exercise on Glycaemic Control and Selected Markers of Vascular Function in Type 1 Diabetes.
AU - Hall, Barbara
AU - Zebrowska, Aleksandra
AU - Kaminski, Tomasz
AU - Stanula, Arkadiusz
AU - Robins, Anna
PY - 2018
Y1 - 2018
N2 - Objectives The aim of the study was to assess the effect of continuous and intermittent exercise in hypoxia on glycaemic control and selected markers of vascular function in patients with Type 1 diabetes (T1D).
Methods 12 patients suffering from T1D for 12.1±6.0 years and 12 healthy adults performed: continuous exercise (ExC) and intermittent exercise (ExInt) in normoxia and hypoxia (FiO₂=15.1%). Glycaemia and proangiogenic factors concentrations were measured at rest and immediately after exercise.
Results T1D patients’ glycaemia decreased in response to ExC (p<0.01) and ExInt (p<0.05) under hypoxic conditions. ExInt in normoxia (p<0.05) and hypoxia (p<0.05) reduced HIF-1α in the T1D group. A tendency for vascular endothelial growth factor to increase after ExInt in hypoxia (6.0±3.8 vs. 17.1±13.07 pg/mL) and a proinflammatory cytokine TNF-α level to decrease (33.2±19.1 vs. 25.1±14.4 pg/mL) was found in the same group.
Conclusions Combining exercise with hypoxia may allow more effective short-term glycaemic control in T1D. Intermittent exercise with hypoxia could stabilize the secretion of selected proangiogenic factors and reduce inflammation, potentially leading to improved vascular function.
AB - Objectives The aim of the study was to assess the effect of continuous and intermittent exercise in hypoxia on glycaemic control and selected markers of vascular function in patients with Type 1 diabetes (T1D).
Methods 12 patients suffering from T1D for 12.1±6.0 years and 12 healthy adults performed: continuous exercise (ExC) and intermittent exercise (ExInt) in normoxia and hypoxia (FiO₂=15.1%). Glycaemia and proangiogenic factors concentrations were measured at rest and immediately after exercise.
Results T1D patients’ glycaemia decreased in response to ExC (p<0.01) and ExInt (p<0.05) under hypoxic conditions. ExInt in normoxia (p<0.05) and hypoxia (p<0.05) reduced HIF-1α in the T1D group. A tendency for vascular endothelial growth factor to increase after ExInt in hypoxia (6.0±3.8 vs. 17.1±13.07 pg/mL) and a proinflammatory cytokine TNF-α level to decrease (33.2±19.1 vs. 25.1±14.4 pg/mL) was found in the same group.
Conclusions Combining exercise with hypoxia may allow more effective short-term glycaemic control in T1D. Intermittent exercise with hypoxia could stabilize the secretion of selected proangiogenic factors and reduce inflammation, potentially leading to improved vascular function.
UR - http://usir.salford.ac.uk/id/eprint/44113/
U2 - 10.1055/s-0043-110482
DO - 10.1055/s-0043-110482
M3 - Article
SN - 0947-7349
VL - 126
SP - 229
EP - 241
JO - Experimental and Clinical Endocrinology and Diabetes
JF - Experimental and Clinical Endocrinology and Diabetes
IS - 04
ER -
