Effects of malaria on O2 consumption and brown adipose tissue activity in mice

A. L. Cooper, M. J. Dascombe, N. J. Rothwell, M. J. Vale

Research output: Contribution to journalArticlepeer-review


Increased energy expenditure often occurs during illness or after injection of endotoxin and can contribute to the generation of fever. In laboratory rats and mice the thermogenic response has been attributed to the sympathetic activation of brown adipose tissue (BAT), although mice often fail to show pyrexia. In this study the effects of malaria on O2 consumption and BAT were studied in mice inoculated with Plasmodium berghei. Parasitemia was maximal (>50% of erythrocytes showing positive Leishman staining) 72 h after inoculation. Up to this time body weight and food intake were similar to values for control mice, although colonic temperatures were slightly depressed in infected mice. Thereafter, infected mice showed marked hypophagia, loss of body weight, and severe hypothermia; colonic temperature was
Original languageEnglish
Pages (from-to)1020-1023
Number of pages3
JournalJournal of Applied Physiology
Issue number3
Publication statusPublished - 1989


  • Animals
  • Body Temperature Regulation
  • physiopathology: Brown Fat
  • Energy Metabolism
  • metabolism: Guanosine Diphosphate
  • physiopathology: Malaria
  • Male
  • Mice
  • metabolism: Mitochondria
  • Oxygen Consumption
  • Plasmodium berghei
  • Support, Non-U.S. Gov't


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