Effects of methylxanthine drugs on pyrogen-induced hyperthermia

M. J. Dascombe

    Research output: Contribution to journalArticlepeer-review


    The hyperthermic response to pyrogen was not potentiated by caffeine or theophylline administered i.p. into cats or rabbit. Injection of these drugs into the anterior hypothalamus or into the third cerebral ventricle in cats was also without effect on pyrexia. These results support the hypothesis that cyclic AMP in the anterior hypothalamus does not mediate pyrogen induced hyperthermia in cats.
    Original languageEnglish
    Pages (from-to)389-392
    Number of pages3
    JournalEuropean journal of pharmacology
    Issue number4
    Publication statusPublished - 1977


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