Effects of the anti-cancer agent etoposide on human herpesvirus 1 replication in vitro

A. G. Lewis; G M Cleator; P E Klapper; P P Templeton; M Longson

doi:10.1016/s0923-2516(89)80122-0

Effects of the anti-cancer agent etoposide on human herpesvirus 1 replication in vitro

A. G. Lewis, G M Cleator, P E Klapper, P P Templeton, M Longson

Division of Evolution, Infection and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

The anti-human herpesvirus type 1 (herpes simplex virus 1; HSV1) activity of etoposide (VP-16-213, a semi-synthetic derivative of epipodophyllotoxin) was investigated in vitro. Etoposide (but not the proprietary solvent in which the compound is usually formulated) demonstrated a significant antiviral action, probably through an effect on virus replication. Etoposide, at 3 micrograms/ml, induced a 50% reduction of HSV1-plaque formation in Vero cells. These findings are considered in the context of the use of etoposide in an in vivo procedure for the diagnosis of herpes encephalitis through virus-specific scintigraphic brain imaging.

Original language	English
Pages (from-to)	443-451
Number of pages	9
Journal	Research in virology
Volume	140
Issue number	5
DOIs	https://doi.org/10.1016/s0923-2516(89)80122-0
Publication status	Published - 1 Jun 1989

Keywords

Animals
Cell Division/drug effects
Etoposide/pharmacology
Humans
Simplexvirus/drug effects
Vero Cells
Viral Plaque Assay
Virus Replication/drug effects

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/s0923-2516(89)80122-0

Cite this

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title = "Effects of the anti-cancer agent etoposide on human herpesvirus 1 replication in vitro",

abstract = "The anti-human herpesvirus type 1 (herpes simplex virus 1; HSV1) activity of etoposide (VP-16-213, a semi-synthetic derivative of epipodophyllotoxin) was investigated in vitro. Etoposide (but not the proprietary solvent in which the compound is usually formulated) demonstrated a significant antiviral action, probably through an effect on virus replication. Etoposide, at 3 micrograms/ml, induced a 50% reduction of HSV1-plaque formation in Vero cells. These findings are considered in the context of the use of etoposide in an in vivo procedure for the diagnosis of herpes encephalitis through virus-specific scintigraphic brain imaging.",

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author = "Lewis, {A. G.} and Cleator, {G M} and Klapper, {P E} and Templeton, {P P} and M Longson",

year = "1989",

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doi = "10.1016/s0923-2516(89)80122-0",

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T1 - Effects of the anti-cancer agent etoposide on human herpesvirus 1 replication in vitro

AU - Lewis, A. G.

AU - Cleator, G M

AU - Klapper, P E

AU - Templeton, P P

AU - Longson, M

PY - 1989/6/1

Y1 - 1989/6/1

N2 - The anti-human herpesvirus type 1 (herpes simplex virus 1; HSV1) activity of etoposide (VP-16-213, a semi-synthetic derivative of epipodophyllotoxin) was investigated in vitro. Etoposide (but not the proprietary solvent in which the compound is usually formulated) demonstrated a significant antiviral action, probably through an effect on virus replication. Etoposide, at 3 micrograms/ml, induced a 50% reduction of HSV1-plaque formation in Vero cells. These findings are considered in the context of the use of etoposide in an in vivo procedure for the diagnosis of herpes encephalitis through virus-specific scintigraphic brain imaging.

AB - The anti-human herpesvirus type 1 (herpes simplex virus 1; HSV1) activity of etoposide (VP-16-213, a semi-synthetic derivative of epipodophyllotoxin) was investigated in vitro. Etoposide (but not the proprietary solvent in which the compound is usually formulated) demonstrated a significant antiviral action, probably through an effect on virus replication. Etoposide, at 3 micrograms/ml, induced a 50% reduction of HSV1-plaque formation in Vero cells. These findings are considered in the context of the use of etoposide in an in vivo procedure for the diagnosis of herpes encephalitis through virus-specific scintigraphic brain imaging.

KW - Animals

KW - Cell Division/drug effects

KW - Etoposide/pharmacology

KW - Humans

KW - Simplexvirus/drug effects

KW - Vero Cells

KW - Viral Plaque Assay

KW - Virus Replication/drug effects

U2 - 10.1016/s0923-2516(89)80122-0

DO - 10.1016/s0923-2516(89)80122-0

M3 - Article

C2 - 2555854

SN - 0923-2516

VL - 140

SP - 443

EP - 451

JO - Research in virology

JF - Research in virology

IS - 5

ER -

Effects of the anti-cancer agent etoposide on human herpesvirus 1 replication in vitro

Abstract

Keywords

UN SDGs

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