Efficacy and Tolerability of Limited Field Radiotherapy with Concurrent Capecitabine in Locally Advanced Pancreatic Cancer

A. S N Jackson, P. Jain, G. R. Watkins, G. A. Whitfield, M. M. Green, J. Valle, M. B. Taylor, C. Dickinson, P. M. Price, A. Saleem

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Aims: Patients with locally advanced pancreatic cancer (LAPC) are most commonly managed with chemotherapy or concurrent chemoradiotherapy (CRT), which may or may not include non-involved regional lymph nodes in the clinical target volume. We present our results of CRT for LAPC using capecitabine and delivering radiotherapy to a limited radiation field that excluded non-involved regional lymph nodes from the clinical target volume. Materials and methods: Thirty patients were studied. Patients received 50.4Gy external beam radiotherapy in 28 fractions, delivered to a planning target volume expanded from the primary tumour and involved nodes only. Capecitabine (500-600mg/m2) was given twice daily continuously during radiotherapy. Toxicity and efficacy data were prospectively collected. Results: Nausea, vomiting and tumour pain were the most common grade 2 toxicities. One patient developed grade 3 nausea. The median time to progression was 8.8 months, with 20% remaining progression free at 1 year. The median overall survival was 9.7 months with a 1 year survival of 30%. Of 21 patients with imaged progression, 13 (62%) progressed systemically, three (14%) had local progression, two (10%) had locoregional progression and three (14%) progressed with both local/locoregional and systemic disease. Conclusion: CRT using capecitabine and limited field radiotherapy is a well-tolerated, relatively efficacious treatment for LAPC. The low toxicity and low regional progression rates support the use of limited field radiotherapy, allowing evaluation of this regimen with other anti-cancer agents. © 2010 The Royal College of Radiologists.
    Original languageEnglish
    Pages (from-to)570-577
    Number of pages7
    JournalClinical Oncology
    Volume22
    Issue number7
    DOIs
    Publication statusPublished - Sept 2010

    Keywords

    • Capecitabine
    • Chemoradiotherapy
    • Limited field
    • Locally advanced pancreatic cancer

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