Efficacy of Alteplase ® in a mouse model of acute ischemic stroke: a retrospective pooled analysis

Cyrille Orset PhD, Benoit Haelewyn PhD, Stuart M. Allan PhD, Saema Ansar PhD, Francesco Campos PhD, Hee Cho MD. Tae, Durand MD. Anne, Mohamad El Amki PhD, Fatar MD. Marc, Isaac Garcia-Yébenes PhD, Maxime Gauberti PhD, Saskia Grudzenski PhD, Lizasoain MD. Ignacio, Lo MD. Eng, Richard Macrez PhD, Isabelle Margaill PhD, Samaneh Maysami, Meairs MD. Stephen, Nighoghossian MD. Norbert, Josune Orbe PhDAntonio Paramo MD. Jose, Jean-Jacques Parienti PhD, Nancy Rothwell, Marina Rubio PhD, Christian Waeber PhD, Alan R. Young PhD, Emmanuel Touzé PhD, Denis Vivien PhD

Research output: Contribution to journalArticlepeer-review

Abstract

Background and purpose: The debate over the fact that experimental drugs proposed for the treatment of stroke fail in the translation to the clinical situation, has attracted considerable attention in the literature. In this context, we present a retrospective pooled analysis of a large dataset from pre-clinical studies, in order to examine the effects of early versus late administration of intravenous recombinant tissue type plasminogen activator (rt-PA). Methods: We collected data from 26 individual studies from 9 international centers (13 researchers, 716 animals) that compared rt-PA to controls, in a unique mouse model of thromboembolic stroke induced by an in situ injection of thrombin into the middle cerebral artery. Studies were classified into early (
Original languageEnglish
JournalStroke
Publication statusPublished - 2016

Keywords

  • stroke; experimental models; tissue-type plasminogen activator; fibrinolysis; meta-analysis

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