TY - JOUR
T1 - Efficacy of Alteplase ® in a mouse model of acute ischemic stroke: a retrospective pooled analysis
AU - PhD, Cyrille Orset
AU - PhD, Benoit Haelewyn
AU - PhD, Stuart M. Allan
AU - PhD, Saema Ansar
AU - PhD, Francesco Campos
AU - Tae, Hee Cho MD.
AU - Anne, Durand MD.
AU - PhD, Mohamad El Amki
AU - Marc, Fatar MD.
AU - PhD, Isaac Garcia-Yébenes
AU - PhD, Maxime Gauberti
AU - PhD, Saskia Grudzenski
AU - Ignacio, Lizasoain MD.
AU - Eng, Lo MD.
AU - PhD, Richard Macrez
AU - PhD, Isabelle Margaill
AU - Maysami, Samaneh
AU - Stephen, Meairs MD.
AU - Norbert, Nighoghossian MD.
AU - PhD, Josune Orbe
AU - Jose, Antonio Paramo MD.
AU - PhD, Jean-Jacques Parienti
AU - Rothwell, Nancy
AU - PhD, Marina Rubio
AU - PhD, Christian Waeber
AU - PhD, Alan R. Young
AU - PhD, Emmanuel Touzé
AU - PhD, Denis Vivien
PY - 2016
Y1 - 2016
N2 - Background and purpose: The debate over the fact that experimental drugs proposed for the treatment of stroke fail in the translation to the clinical situation, has attracted considerable attention in the literature. In this context, we present a retrospective pooled analysis of a large dataset from pre-clinical studies, in order to examine the effects of early versus late administration of intravenous recombinant tissue type plasminogen activator (rt-PA). Methods: We collected data from 26 individual studies from 9 international centers (13 researchers, 716 animals) that compared rt-PA to controls, in a unique mouse model of thromboembolic stroke induced by an in situ injection of thrombin into the middle cerebral artery. Studies were classified into early (
AB - Background and purpose: The debate over the fact that experimental drugs proposed for the treatment of stroke fail in the translation to the clinical situation, has attracted considerable attention in the literature. In this context, we present a retrospective pooled analysis of a large dataset from pre-clinical studies, in order to examine the effects of early versus late administration of intravenous recombinant tissue type plasminogen activator (rt-PA). Methods: We collected data from 26 individual studies from 9 international centers (13 researchers, 716 animals) that compared rt-PA to controls, in a unique mouse model of thromboembolic stroke induced by an in situ injection of thrombin into the middle cerebral artery. Studies were classified into early (
KW - stroke; experimental models; tissue-type plasminogen activator; fibrinolysis; meta-analysis
M3 - Article
JO - Stroke; a journal of cerebral circulation
JF - Stroke; a journal of cerebral circulation
SN - 0039-2499
ER -