Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Jeroen Van Den Bossche; Wafa T. Al-Jamal; Bowen Tian; Antonio Nunes; Chiara Fabbro; Alberto Bianco; Maurizio Prato; Kostas Kostarelos

doi:10.1039/c0cc02092c

Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Jeroen Van Den Bossche, Wafa T. Al-Jamal, Bowen Tian, Antonio Nunes, Chiara Fabbro, Alberto Bianco, Maurizio Prato, Kostas Kostarelos

Research output: Contribution to journal › Article › peer-review

Abstract

We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications. © 2010 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	7379-7381
Number of pages	2
Journal	Chemical Communications
Volume	46
Issue number	39
DOIs	https://doi.org/10.1039/c0cc02092c
Publication status	Published - 21 Oct 2010

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abstract = "We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications. {\textcopyright} 2010 The Royal Society of Chemistry.",

author = "{Van Den Bossche}, Jeroen and Al-Jamal, {Wafa T.} and Bowen Tian and Antonio Nunes and Chiara Fabbro and Alberto Bianco and Maurizio Prato and Kostas Kostarelos",

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AU - Van Den Bossche, Jeroen

AU - Al-Jamal, Wafa T.

AU - Tian, Bowen

AU - Nunes, Antonio

AU - Fabbro, Chiara

AU - Bianco, Alberto

AU - Prato, Maurizio

AU - Kostarelos, Kostas

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PY - 2010/10/21

Y1 - 2010/10/21

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AB - We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications. © 2010 The Royal Society of Chemistry.

U2 - 10.1039/c0cc02092c

DO - 10.1039/c0cc02092c

M3 - Article

SN - 1359-7345

VL - 46

SP - 7379

EP - 7381

JO - Chemical Communications

JF - Chemical Communications

IS - 39

ER -

Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Abstract

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