Eicosanoids in skin inflammation

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    Eicosanoids play an integral part in homeostatic mechanisms related to skin health and structural integrity. They also mediate inflammatory events developed in response to environmental factors, such as exposure to ultraviolet radiation, and inflammatory and allergic disorders, including psoriasis and atopic dermatitis. This review article discusses biochemical aspects related to cutaneous eicosanoid metabolism, the contribution of these potent autacoids to skin inflammation and related conditions, and considers the importance of nutritional supplementation with bioactives such as omega-3 and omega-6 polyunsaturated fatty acids and plant-derived antioxidants as means of addressing skin health issues. © 2012 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)131-138
    Number of pages7
    JournalProstaglandins, Leukotrienes & Essential Fatty Acids
    Issue number1
    Publication statusPublished - Jan 2013


    • Eicosanoids
    • Inflammation
    • Polyunsaturated fatty acids
    • Skin


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