Elastic Fibre Proteins in Elastogenesis and Wound Healing

Xinyang Zhang; Yasmene F Alanazi; Thomas A Jowitt; Alan M Roseman; Clair Baldock

doi:10.3390/ijms23084087

Elastic Fibre Proteins in Elastogenesis and Wound Healing

Xinyang Zhang, Yasmene F Alanazi, Thomas A Jowitt, Alan M Roseman, Clair Baldock

Research output: Contribution to journal › Review article › peer-review

Abstract

As essential components of our connective tissues, elastic fibres give tissues such as major blood vessels, skin and the lungs their elasticity. Their formation is complex and co-ordinately regulated by multiple factors. In this review, we describe key players in elastogenesis: fibrillin-1, tropoelastin, latent TGFβ binding protein-4, and fibulin-4 and -5. We summarise their roles in elastogenesis, discuss the effect of their mutations on relevant diseases, and describe their interactions involved in forming the elastic fibre network. Moreover, we look into their roles in wound repair for a better understanding of their potential application in tissue regeneration.

Original language	English
Pages (from-to)	4087
Journal	International Journal of Molecular Sciences
Volume	23
Issue number	8
DOIs	https://doi.org/10.3390/ijms23084087
Publication status	Published - 7 Apr 2022

Keywords

Connective Tissue/metabolism
Elastic Tissue/metabolism
Extracellular Matrix Proteins/metabolism
Latent TGF-beta Binding Proteins/metabolism
Tropoelastin/genetics
Wound Healing/genetics

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10.3390/ijms23084087

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title = "Elastic Fibre Proteins in Elastogenesis and Wound Healing",

abstract = "As essential components of our connective tissues, elastic fibres give tissues such as major blood vessels, skin and the lungs their elasticity. Their formation is complex and co-ordinately regulated by multiple factors. In this review, we describe key players in elastogenesis: fibrillin-1, tropoelastin, latent TGFβ binding protein-4, and fibulin-4 and -5. We summarise their roles in elastogenesis, discuss the effect of their mutations on relevant diseases, and describe their interactions involved in forming the elastic fibre network. Moreover, we look into their roles in wound repair for a better understanding of their potential application in tissue regeneration.",

keywords = "Connective Tissue/metabolism, Elastic Tissue/metabolism, Extracellular Matrix Proteins/metabolism, Latent TGF-beta Binding Proteins/metabolism, Tropoelastin/genetics, Wound Healing/genetics",

author = "Xinyang Zhang and Alanazi, {Yasmene F} and Jowitt, {Thomas A} and Roseman, {Alan M} and Clair Baldock",

year = "2022",

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doi = "10.3390/ijms23084087",

language = "English",

volume = "23",

pages = "4087",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

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TY - JOUR

T1 - Elastic Fibre Proteins in Elastogenesis and Wound Healing

AU - Zhang, Xinyang

AU - Alanazi, Yasmene F

AU - Jowitt, Thomas A

AU - Roseman, Alan M

AU - Baldock, Clair

PY - 2022/4/7

Y1 - 2022/4/7

N2 - As essential components of our connective tissues, elastic fibres give tissues such as major blood vessels, skin and the lungs their elasticity. Their formation is complex and co-ordinately regulated by multiple factors. In this review, we describe key players in elastogenesis: fibrillin-1, tropoelastin, latent TGFβ binding protein-4, and fibulin-4 and -5. We summarise their roles in elastogenesis, discuss the effect of their mutations on relevant diseases, and describe their interactions involved in forming the elastic fibre network. Moreover, we look into their roles in wound repair for a better understanding of their potential application in tissue regeneration.

AB - As essential components of our connective tissues, elastic fibres give tissues such as major blood vessels, skin and the lungs their elasticity. Their formation is complex and co-ordinately regulated by multiple factors. In this review, we describe key players in elastogenesis: fibrillin-1, tropoelastin, latent TGFβ binding protein-4, and fibulin-4 and -5. We summarise their roles in elastogenesis, discuss the effect of their mutations on relevant diseases, and describe their interactions involved in forming the elastic fibre network. Moreover, we look into their roles in wound repair for a better understanding of their potential application in tissue regeneration.

KW - Connective Tissue/metabolism

KW - Elastic Tissue/metabolism

KW - Extracellular Matrix Proteins/metabolism

KW - Latent TGF-beta Binding Proteins/metabolism

KW - Tropoelastin/genetics

KW - Wound Healing/genetics

U2 - 10.3390/ijms23084087

DO - 10.3390/ijms23084087

M3 - Review article

C2 - 35456902

SN - 1661-6596

VL - 23

SP - 4087

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 8

ER -

Elastic Fibre Proteins in Elastogenesis and Wound Healing

Abstract

Keywords

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