Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

Clare F. Megarity; Bhavin Siritanaratkul; Rachel S. Heath; Lei Wan; Giorgio Morello; Sarah R. FitzPatrick; Rosalind L. Booth; Adam J. Sills; Alexander W. Robertson; Jamie H. Warner; Nicholas J. Turner; Fraser A.  Armstrong

doi:10.1002/ange.201814370

Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

Clare F. Megarity, Bhavin Siritanaratkul, Rachel S. Heath, Lei Wan, Giorgio Morello, Sarah R. FitzPatrick, Rosalind L. Booth, Adam J. Sills, Alexander W. Robertson, Jamie H. Warner, Nicholas J. Turner, Fraser A. Armstrong

Materials Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP+ are cycled rapidly between ferredoxin–NADP+ reductase and a second enzyme—the pairs being juxtaposed within the 5–100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme-catalysed reactions.

Original language	English
Pages (from-to)	5002-5006
Number of pages	5
Journal	Angewandte Chemie
Volume	131
Issue number	15
Early online date	11 Jan 2019
DOIs	https://doi.org/10.1002/ange.201814370
Publication status	Published - 1 Apr 2019

Keywords

cofactor recycling
electrocatalysis
ferredoxin NADP reductase
nanoconfinement
nicotinamide
ferredoxin NADP + reductase

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

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10.1002/ange.201814370

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Megarity, C. F., Siritanaratkul, B., Heath, R. S., Wan, L., Morello, G., FitzPatrick, S. R., Booth, R. L., Sills, A. J., Robertson, A. W., Warner, J. H., Turner, N. J., & Armstrong, F. A. (2019). Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores. Angewandte Chemie, 131(15), 5002-5006. https://doi.org/10.1002/ange.201814370

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title = "Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores",

abstract = "In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP+ are cycled rapidly between ferredoxin–NADP+ reductase and a second enzyme—the pairs being juxtaposed within the 5–100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme-catalysed reactions.",

keywords = "cofactor recycling, electrocatalysis, ferredoxin NADP reductase, nanoconfinement, nicotinamide, ferredoxin NADP + reductase",

author = "Megarity, {Clare F.} and Bhavin Siritanaratkul and Heath, {Rachel S.} and Lei Wan and Giorgio Morello and FitzPatrick, {Sarah R.} and Booth, {Rosalind L.} and Sills, {Adam J.} and Robertson, {Alexander W.} and Warner, {Jamie H.} and Turner, {Nicholas J.} and Armstrong, {Fraser A.}",

year = "2019",

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day = "1",

doi = "10.1002/ange.201814370",

language = "English",

volume = "131",

pages = "5002--5006",

journal = "Angewandte Chemie",

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TY - JOUR

T1 - Electrocatalytic Volleyball

T2 - Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

AU - Megarity, Clare F.

AU - Siritanaratkul, Bhavin

AU - Heath, Rachel S.

AU - Wan, Lei

AU - Morello, Giorgio

AU - FitzPatrick, Sarah R.

AU - Booth, Rosalind L.

AU - Sills, Adam J.

AU - Robertson, Alexander W.

AU - Warner, Jamie H.

AU - Turner, Nicholas J.

AU - Armstrong, Fraser A.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP+ are cycled rapidly between ferredoxin–NADP+ reductase and a second enzyme—the pairs being juxtaposed within the 5–100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme-catalysed reactions.

AB - In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP+ are cycled rapidly between ferredoxin–NADP+ reductase and a second enzyme—the pairs being juxtaposed within the 5–100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme-catalysed reactions.

KW - cofactor recycling

KW - electrocatalysis

KW - ferredoxin NADP reductase

KW - nanoconfinement

KW - nicotinamide

KW - ferredoxin NADP + reductase

UR - https://doi.org/10.1002/ange.201814370

U2 - 10.1002/ange.201814370

DO - 10.1002/ange.201814370

M3 - Article

SN - 0044-8249

VL - 131

SP - 5002

EP - 5006

JO - Angewandte Chemie

JF - Angewandte Chemie

IS - 15

ER -

Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

Abstract

Keywords

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