Electrochemical and photophysical properties of DNA metallo-intercalators containing the ruthenium(II) tris(1-pyrazolyl)methane unit

Simon P. Foxon, Clive Metcalfe, Harry Adams, Michelle Webb, Jim A. Thomas

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Three new ruthenium(II) complexes containing the tris(1-pyrazolyl)methane (tpm) ligand have been prepared: [Ru-(tpm)(L)(dppn)]n+ (where n = 1; L = Cl (5), n = 2; L = MeCN (6) and pyridine (7); dppn = benzo[i]dipyrido-[3,2- a:2′,3′-c]phenazine). Complex 6 was structurally characterized by single-crystal X-ray diffraction. Binding parameters of these complexes with calf thymus DNA are reported and compared to those obtained for a previously reported monocation, [RuCl(tpm)(dppz)]+. Binding studies with the dications and the synthetic oligonucleotides poly(dA)·poly(dT) and poly(dG)·poly(dC) have also been determined. Photophysical and electrochemical properties of 5-7 have been investigated and compared with their dipyridophenazine (dppz) analogues. © 2007 American Chemical Society.
    Original languageEnglish
    Pages (from-to)409-416
    Number of pages7
    JournalInorganic Chemistry: including bioinorganic chemistry
    Volume46
    Issue number2
    DOIs
    Publication statusPublished - 22 Jan 2007

    Keywords

    • Crystallography, X-Ray
    • chemistry: DNA
    • Electrochemistry
    • chemistry: Intercalating Agents
    • Magnetic Resonance Spectroscopy
    • Models, Molecular
    • chemistry: Organometallic Compounds
    • Spectrometry, Mass, Fast Atom Bombardment
    • Stereoisomerism

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