Electrochemical and photophysical properties of DNA metallo-intercalators containing the ruthenium(II) tris(1-pyrazolyl)methane unit

Simon P. Foxon; Clive Metcalfe; Harry Adams; Michelle Webb; Jim A. Thomas

doi:10.1021/ic0607134

Electrochemical and photophysical properties of DNA metallo-intercalators containing the ruthenium(II) tris(1-pyrazolyl)methane unit

Simon P. Foxon, Clive Metcalfe, Harry Adams, Michelle Webb, Jim A. Thomas

Research output: Contribution to journal › Article › peer-review

Abstract

Three new ruthenium(II) complexes containing the tris(1-pyrazolyl)methane (tpm) ligand have been prepared: [Ru-(tpm)(L)(dppn)]n+ (where n = 1; L = Cl (5), n = 2; L = MeCN (6) and pyridine (7); dppn = benzo[i]dipyrido-[3,2- a:2′,3′-c]phenazine). Complex 6 was structurally characterized by single-crystal X-ray diffraction. Binding parameters of these complexes with calf thymus DNA are reported and compared to those obtained for a previously reported monocation, [RuCl(tpm)(dppz)]+. Binding studies with the dications and the synthetic oligonucleotides poly(dA)·poly(dT) and poly(dG)·poly(dC) have also been determined. Photophysical and electrochemical properties of 5-7 have been investigated and compared with their dipyridophenazine (dppz) analogues. © 2007 American Chemical Society.

Original language	English
Pages (from-to)	409-416
Number of pages	7
Journal	Inorganic Chemistry: including bioinorganic chemistry
Volume	46
Issue number	2
DOIs	https://doi.org/10.1021/ic0607134
Publication status	Published - 22 Jan 2007

Keywords

Crystallography, X-Ray
chemistry: DNA
Electrochemistry
chemistry: Intercalating Agents
Magnetic Resonance Spectroscopy
Models, Molecular
chemistry: Organometallic Compounds
Spectrometry, Mass, Fast Atom Bombardment
Stereoisomerism

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10.1021/ic0607134

CCDC 639511: Experimental Crystal Structure Determination
Foxon, S. P. (Contributor), Metcalfe, C. (Contributor), Adams, H. (Contributor), Webb, M. (Contributor) & Thomas, J. A. (Contributor), Cambridge Crystallographic Data Centre, 2007
DOI: 10.5517/ccpggdz, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccpggdz&sid=DataCite
Dataset

Cite this

@article{1414d2bb18b04fb9b63f2db949e2a2d3,

title = "Electrochemical and photophysical properties of DNA metallo-intercalators containing the ruthenium(II) tris(1-pyrazolyl)methane unit",

abstract = "Three new ruthenium(II) complexes containing the tris(1-pyrazolyl)methane (tpm) ligand have been prepared: [Ru-(tpm)(L)(dppn)]n+ (where n = 1; L = Cl (5), n = 2; L = MeCN (6) and pyridine (7); dppn = benzo[i]dipyrido-[3,2- a:2′,3′-c]phenazine). Complex 6 was structurally characterized by single-crystal X-ray diffraction. Binding parameters of these complexes with calf thymus DNA are reported and compared to those obtained for a previously reported monocation, [RuCl(tpm)(dppz)]+. Binding studies with the dications and the synthetic oligonucleotides poly(dA)·poly(dT) and poly(dG)·poly(dC) have also been determined. Photophysical and electrochemical properties of 5-7 have been investigated and compared with their dipyridophenazine (dppz) analogues. {\textcopyright} 2007 American Chemical Society.",

keywords = "Crystallography, X-Ray, chemistry: DNA, Electrochemistry, chemistry: Intercalating Agents, Magnetic Resonance Spectroscopy, Models, Molecular, chemistry: Organometallic Compounds, Spectrometry, Mass, Fast Atom Bombardment, Stereoisomerism",

author = "Foxon, {Simon P.} and Clive Metcalfe and Harry Adams and Michelle Webb and Thomas, {Jim A.}",

year = "2007",

month = jan,

day = "22",

doi = "10.1021/ic0607134",

language = "English",

volume = "46",

pages = "409--416",

journal = "Inorganic Chemistry",

issn = "0020-1669",

publisher = "American Chemical Society",

number = "2",

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TY - JOUR

T1 - Electrochemical and photophysical properties of DNA metallo-intercalators containing the ruthenium(II) tris(1-pyrazolyl)methane unit

AU - Foxon, Simon P.

AU - Metcalfe, Clive

AU - Adams, Harry

AU - Webb, Michelle

AU - Thomas, Jim A.

PY - 2007/1/22

Y1 - 2007/1/22

N2 - Three new ruthenium(II) complexes containing the tris(1-pyrazolyl)methane (tpm) ligand have been prepared: [Ru-(tpm)(L)(dppn)]n+ (where n = 1; L = Cl (5), n = 2; L = MeCN (6) and pyridine (7); dppn = benzo[i]dipyrido-[3,2- a:2′,3′-c]phenazine). Complex 6 was structurally characterized by single-crystal X-ray diffraction. Binding parameters of these complexes with calf thymus DNA are reported and compared to those obtained for a previously reported monocation, [RuCl(tpm)(dppz)]+. Binding studies with the dications and the synthetic oligonucleotides poly(dA)·poly(dT) and poly(dG)·poly(dC) have also been determined. Photophysical and electrochemical properties of 5-7 have been investigated and compared with their dipyridophenazine (dppz) analogues. © 2007 American Chemical Society.

AB - Three new ruthenium(II) complexes containing the tris(1-pyrazolyl)methane (tpm) ligand have been prepared: [Ru-(tpm)(L)(dppn)]n+ (where n = 1; L = Cl (5), n = 2; L = MeCN (6) and pyridine (7); dppn = benzo[i]dipyrido-[3,2- a:2′,3′-c]phenazine). Complex 6 was structurally characterized by single-crystal X-ray diffraction. Binding parameters of these complexes with calf thymus DNA are reported and compared to those obtained for a previously reported monocation, [RuCl(tpm)(dppz)]+. Binding studies with the dications and the synthetic oligonucleotides poly(dA)·poly(dT) and poly(dG)·poly(dC) have also been determined. Photophysical and electrochemical properties of 5-7 have been investigated and compared with their dipyridophenazine (dppz) analogues. © 2007 American Chemical Society.

KW - Crystallography, X-Ray

KW - chemistry: DNA

KW - Electrochemistry

KW - chemistry: Intercalating Agents

KW - Magnetic Resonance Spectroscopy

KW - Models, Molecular

KW - chemistry: Organometallic Compounds

KW - Spectrometry, Mass, Fast Atom Bombardment

KW - Stereoisomerism

U2 - 10.1021/ic0607134

DO - 10.1021/ic0607134

M3 - Article

VL - 46

SP - 409

EP - 416

JO - Inorganic Chemistry

JF - Inorganic Chemistry

SN - 0020-1669

IS - 2

ER -

Electrochemical and photophysical properties of DNA metallo-intercalators containing the ruthenium(II) tris(1-pyrazolyl)methane unit

Abstract

Keywords

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CCDC 639511: Experimental Crystal Structure Determination

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