Abstract
(Chemical Equation Presented) Treatment of N-arylisonicotinamides with trifluoromethanesulfonic anhydride triggers intramolecular nucleophilic attack of the aryl ring on the 4-position of the pyridinium intermediate. The products are spirocyclic dihydropyridines which can be converted to valuable spirocyclic piperidines related to biologically active molecules such as MK-677. © 2008 American Chemical Society.
Original language | English |
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Pages (from-to) | 3089-3092 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 10 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2008 |
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CCDC 676939: Experimental Crystal Structure Determination
Arnott, G. (Contributor), Brice, H. (Contributor), Clayden, J. (Contributor) & Blaney, E. (Contributor), Cambridge Crystallographic Data Centre, 2008
DOI: 10.5517/ccqqdrk, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccqqdrk&sid=DataCite
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