Electrophysiological substrate for a dominant reentrant source during atrial fibrillation.

Oleg V Aslanidi; Robert Robinson; Deborah Cheverton; Mark R Boyett; Henggui Zhang; MR Boyett

doi:10.1109/IEMBS.2009.5333573

Electrophysiological substrate for a dominant reentrant source during atrial fibrillation.

Oleg V Aslanidi, Robert Robinson, Deborah Cheverton, Mark R Boyett, Henggui Zhang, MR Boyett

Research output: Contribution to journal › Article › peer-review

Abstract

Experimentally observed differences in the action potential (AP) properties between the left (LA) and right (RA) atria are believed to be important in maintaining reentrant sources during atrial fibrillation. We incorporate AP models for single LA and RA cells, as well as major intra- and interatrial conduction pathways, into a 2D atrial tissue model and study the role of tissue heterogeneity in global interactions between reentrant spiral waves in both atria. Our simulations show that shorter AP refractoriness in the LA translates into a shorter period of spiral rotation, and as a result, reentry in the LA dominates the overall excitation patterns in the atria.

Original language	English
Article number	5333573
Pages (from-to)	2819-2822
Number of pages	3
Journal	Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
Volume	2009
DOIs	https://doi.org/10.1109/IEMBS.2009.5333573
Publication status	Published - 2009

Keywords

Action Potentials/physiology
Animals
Atrial Fibrillation/*physiopathology
Biomedical Engineering/methods
Computer Simulation
Electrophysiology/*methods
Heart/physiology
Heart Atria/pathology
Heart Conduction System/physiology
Humans
Membrane Potentials
Rabbits
Signal Processing, Computer-Assisted

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10.1109/IEMBS.2009.5333573

http://www.ncbi.nlm.nih.gov/pubmed/19964268

Cite this

Aslanidi, O. V., Robinson, R., Cheverton, D., Boyett, M. R., Zhang, H., & Boyett, MR. (2009). Electrophysiological substrate for a dominant reentrant source during atrial fibrillation. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2009, 2819-2822. Article 5333573. https://doi.org/10.1109/IEMBS.2009.5333573

Aslanidi, Oleg V ; Robinson, Robert ; Cheverton, Deborah et al. / Electrophysiological substrate for a dominant reentrant source during atrial fibrillation. In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2009 ; Vol. 2009. pp. 2819-2822.

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title = "Electrophysiological substrate for a dominant reentrant source during atrial fibrillation.",

abstract = "Experimentally observed differences in the action potential (AP) properties between the left (LA) and right (RA) atria are believed to be important in maintaining reentrant sources during atrial fibrillation. We incorporate AP models for single LA and RA cells, as well as major intra- and interatrial conduction pathways, into a 2D atrial tissue model and study the role of tissue heterogeneity in global interactions between reentrant spiral waves in both atria. Our simulations show that shorter AP refractoriness in the LA translates into a shorter period of spiral rotation, and as a result, reentry in the LA dominates the overall excitation patterns in the atria.",

keywords = "Action Potentials/physiology, Animals, Atrial Fibrillation/*physiopathology, Biomedical Engineering/methods, Computer Simulation, Electrophysiology/*methods, Heart/physiology, Heart Atria/pathology, Heart Conduction System/physiology, Humans, Membrane Potentials, Rabbits, Signal Processing, Computer-Assisted",

author = "Aslanidi, {Oleg V} and Robert Robinson and Deborah Cheverton and Boyett, {Mark R} and Henggui Zhang and MR Boyett",

note = "BBS/B/1678X, Biotechnology and Biological Sciences Research Council, United Kingdom",

year = "2009",

doi = "10.1109/IEMBS.2009.5333573",

language = "English",

volume = "2009",

pages = "2819--2822",

journal = "Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference",

publisher = "IEEE",

}

Aslanidi, OV, Robinson, R, Cheverton, D, Boyett, MR, Zhang, H & Boyett, MR 2009, 'Electrophysiological substrate for a dominant reentrant source during atrial fibrillation.', Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2009, 5333573, pp. 2819-2822. https://doi.org/10.1109/IEMBS.2009.5333573

Electrophysiological substrate for a dominant reentrant source during atrial fibrillation. / Aslanidi, Oleg V; Robinson, Robert; Cheverton, Deborah et al.
In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, Vol. 2009, 5333573, 2009, p. 2819-2822.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Electrophysiological substrate for a dominant reentrant source during atrial fibrillation.

AU - Aslanidi, Oleg V

AU - Robinson, Robert

AU - Cheverton, Deborah

AU - Boyett, Mark R

AU - Zhang, Henggui

AU - Boyett, MR

N1 - BBS/B/1678X, Biotechnology and Biological Sciences Research Council, United Kingdom

PY - 2009

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AB - Experimentally observed differences in the action potential (AP) properties between the left (LA) and right (RA) atria are believed to be important in maintaining reentrant sources during atrial fibrillation. We incorporate AP models for single LA and RA cells, as well as major intra- and interatrial conduction pathways, into a 2D atrial tissue model and study the role of tissue heterogeneity in global interactions between reentrant spiral waves in both atria. Our simulations show that shorter AP refractoriness in the LA translates into a shorter period of spiral rotation, and as a result, reentry in the LA dominates the overall excitation patterns in the atria.

KW - Action Potentials/physiology

KW - Animals

KW - Atrial Fibrillation/physiopathology

KW - Biomedical Engineering/methods

KW - Computer Simulation

KW - Electrophysiology/methods

KW - Heart/physiology

KW - Heart Atria/pathology

KW - Heart Conduction System/physiology

KW - Humans

KW - Membrane Potentials

KW - Rabbits

KW - Signal Processing, Computer-Assisted

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DO - 10.1109/IEMBS.2009.5333573

M3 - Article

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VL - 2009

SP - 2819

EP - 2822

JO - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

M1 - 5333573

ER -

Aslanidi OV, Robinson R, Cheverton D, Boyett MR, Zhang H, Boyett MR. Electrophysiological substrate for a dominant reentrant source during atrial fibrillation. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2009;2009:2819-2822. 5333573. doi: 10.1109/IEMBS.2009.5333573

Electrophysiological substrate for a dominant reentrant source during atrial fibrillation.

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Keywords

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