Electrospun Highly Porous Poly(L-lactic acid)-Dopamine- SiO2 Fibrous Membrane for Bone Regeneration

Zihan Lu; Weiguang Wang; Jing Zhang; Paulo Jorge Da Silva Bartolo; Hugh Gong; Jiashen Li

doi:10.1016/j.msec.2020.111359

Electrospun Highly Porous Poly(L-lactic acid)-Dopamine- SiO2 Fibrous Membrane for Bone Regeneration

Zihan Lu, Weiguang Wang, Jing Zhang, Paulo Jorge Da Silva Bartolo, Hugh Gong, Jiashen Li

Xi'an Polytechnic University

Research output: Contribution to journal › Article › peer-review

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Abstract

Electrospinning has been widely used to fabricate polymer fibrous scaffolds for bone tissue engineering because of their highly porous structures. In order to improve the biocompatibility of polymer scaffolds, some nano particles have been introduced into electrospun fibres. For example, silica nanoparticles (SiNPs), with high surface area and good biocompatibility, have been used for
bone tissue engineering for better bone cell attachment. In this work, porous poly(L-lactic acid) (PLLA) fibrous membrane with high surface area was fabricated by electrospinning and posttreatment process. The membrane can serve as substrates of SiNPs for bone tissue engineering. Dopamine (DOP) was applied to modify the surface of PLLA fibres, which improved the coating
strength of SiNPs on PLLA fibres. SiNP coating significantly improved the mechanical properties and hydrophilicity of PLLA/DOP/SiNP composite membranes. As a result of SiNPs coating, PLLA/DOP/SiNP membrane exhibited better cellular biocompatibility, more cell attachment and proliferation. These results demonstrate that porous PLLA/DOP/SiNP composite membrane with
high surface area has high potential for periosteum in the field of bone regeneration applications.

Original language	English
Journal	Materials Science and Engineering C: Materials for Biological Applications
Volume	117
Early online date	11 Aug 2020
DOIs	https://doi.org/10.1016/j.msec.2020.111359
Publication status	Published - 1 Dec 2020

Keywords

dopamine (DOP) grafting
electrospinning
Poly(L-lactic acid)
silica nanoparticle
bone regeneration

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10.1016/j.msec.2020.111359

MSEC_2020_2444_R1aAccepted author manuscript, 1.96 MB

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title = "Electrospun Highly Porous Poly(L-lactic acid)-Dopamine- SiO2 Fibrous Membrane for Bone Regeneration",

abstract = "Electrospinning has been widely used to fabricate polymer fibrous scaffolds for bone tissue engineering because of their highly porous structures. In order to improve the biocompatibility of polymer scaffolds, some nano particles have been introduced into electrospun fibres. For example, silica nanoparticles (SiNPs), with high surface area and good biocompatibility, have been used forbone tissue engineering for better bone cell attachment. In this work, porous poly(L-lactic acid) (PLLA) fibrous membrane with high surface area was fabricated by electrospinning and posttreatment process. The membrane can serve as substrates of SiNPs for bone tissue engineering. Dopamine (DOP) was applied to modify the surface of PLLA fibres, which improved the coatingstrength of SiNPs on PLLA fibres. SiNP coating significantly improved the mechanical properties and hydrophilicity of PLLA/DOP/SiNP composite membranes. As a result of SiNPs coating, PLLA/DOP/SiNP membrane exhibited better cellular biocompatibility, more cell attachment and proliferation. These results demonstrate that porous PLLA/DOP/SiNP composite membrane withhigh surface area has high potential for periosteum in the field of bone regeneration applications.",

keywords = "dopamine (DOP) grafting, electrospinning, Poly(L-lactic acid), silica nanoparticle, bone regeneration",

author = "Zihan Lu and Weiguang Wang and Jing Zhang and {Da Silva Bartolo}, {Paulo Jorge} and Hugh Gong and Jiashen Li",

year = "2020",

month = dec,

day = "1",

doi = "10.1016/j.msec.2020.111359",

language = "English",

volume = "117",

journal = "Materials Science and Engineering C: Materials for Biological Applications ",

issn = "0928-4931",

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TY - JOUR

T1 - Electrospun Highly Porous Poly(L-lactic acid)-Dopamine- SiO2 Fibrous Membrane for Bone Regeneration

AU - Lu, Zihan

AU - Wang, Weiguang

AU - Zhang, Jing

AU - Da Silva Bartolo, Paulo Jorge

AU - Gong, Hugh

AU - Li, Jiashen

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Electrospinning has been widely used to fabricate polymer fibrous scaffolds for bone tissue engineering because of their highly porous structures. In order to improve the biocompatibility of polymer scaffolds, some nano particles have been introduced into electrospun fibres. For example, silica nanoparticles (SiNPs), with high surface area and good biocompatibility, have been used forbone tissue engineering for better bone cell attachment. In this work, porous poly(L-lactic acid) (PLLA) fibrous membrane with high surface area was fabricated by electrospinning and posttreatment process. The membrane can serve as substrates of SiNPs for bone tissue engineering. Dopamine (DOP) was applied to modify the surface of PLLA fibres, which improved the coatingstrength of SiNPs on PLLA fibres. SiNP coating significantly improved the mechanical properties and hydrophilicity of PLLA/DOP/SiNP composite membranes. As a result of SiNPs coating, PLLA/DOP/SiNP membrane exhibited better cellular biocompatibility, more cell attachment and proliferation. These results demonstrate that porous PLLA/DOP/SiNP composite membrane withhigh surface area has high potential for periosteum in the field of bone regeneration applications.

AB - Electrospinning has been widely used to fabricate polymer fibrous scaffolds for bone tissue engineering because of their highly porous structures. In order to improve the biocompatibility of polymer scaffolds, some nano particles have been introduced into electrospun fibres. For example, silica nanoparticles (SiNPs), with high surface area and good biocompatibility, have been used forbone tissue engineering for better bone cell attachment. In this work, porous poly(L-lactic acid) (PLLA) fibrous membrane with high surface area was fabricated by electrospinning and posttreatment process. The membrane can serve as substrates of SiNPs for bone tissue engineering. Dopamine (DOP) was applied to modify the surface of PLLA fibres, which improved the coatingstrength of SiNPs on PLLA fibres. SiNP coating significantly improved the mechanical properties and hydrophilicity of PLLA/DOP/SiNP composite membranes. As a result of SiNPs coating, PLLA/DOP/SiNP membrane exhibited better cellular biocompatibility, more cell attachment and proliferation. These results demonstrate that porous PLLA/DOP/SiNP composite membrane withhigh surface area has high potential for periosteum in the field of bone regeneration applications.

KW - dopamine (DOP) grafting

KW - electrospinning

KW - Poly(L-lactic acid)

KW - silica nanoparticle

KW - bone regeneration

U2 - 10.1016/j.msec.2020.111359

DO - 10.1016/j.msec.2020.111359

M3 - Article

SN - 0928-4931

VL - 117

JO - Materials Science and Engineering C: Materials for Biological Applications

JF - Materials Science and Engineering C: Materials for Biological Applications

ER -

Electrospun Highly Porous Poly(L-lactic acid)-Dopamine- SiO2 Fibrous Membrane for Bone Regeneration

Abstract

Keywords

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