TY - JOUR
T1 - Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer
AU - Li, Xia
AU - Zhou, Jiale
AU - Wu, Haiyan
AU - Dai, Fangyin
A2 - Li, Jiashen
A2 - Li, Zhi
N1 - Funding Information:
This work was supported by the Innovation Program for Chongqing’s Overseas Returnees NO. cx2019090, State Key Laboratory of Silkworm Genome Biology NO. sklsgb-2019KF13, Fundamental Research Funds for the Central Universities NO. XDJK2018B015.
Funding Information:
This research was funded by Southwest University.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/7/18
Y1 - 2022/7/18
N2 - Photothermal therapy is a promising treating method for cancers since it is safe and easily controllable. Black phosphorus (BP) nanosheets have drawn tremendous attention as a novel biodegradable thermotherapy material, owing to their excellent biocompatibility and photothermal properties. In this study, silk fibroin (SF) was used to exfoliate BP with long-term stability and good solution-processability. Then, the prepared BP@SF was introduced into fibrous membranes by electrospinning, together with SF and polylactic-co-glycolic acid (PLGA). The SF/PLGA/BP@SF membranes had relatively smooth and even fibers and the maximum stress was 2.92 MPa. Most importantly, the SF/PLGA/BP@SF membranes exhibited excellent photothermal properties, which could be controlled by the BP@SF content and near infrared (NIR) light power. The temperature of SF/PLGA/BP@SF composite membrane was increased by 15.26 °C under NIR (808 nm, 2.5 W/cm2) irradiation for 10 min. The photothermal property of SF/PLGA/BP@SF membranes significantly killed the HepG2 cancer cells in vitro, indicating its good potential for application in local treatment of cancer.
AB - Photothermal therapy is a promising treating method for cancers since it is safe and easily controllable. Black phosphorus (BP) nanosheets have drawn tremendous attention as a novel biodegradable thermotherapy material, owing to their excellent biocompatibility and photothermal properties. In this study, silk fibroin (SF) was used to exfoliate BP with long-term stability and good solution-processability. Then, the prepared BP@SF was introduced into fibrous membranes by electrospinning, together with SF and polylactic-co-glycolic acid (PLGA). The SF/PLGA/BP@SF membranes had relatively smooth and even fibers and the maximum stress was 2.92 MPa. Most importantly, the SF/PLGA/BP@SF membranes exhibited excellent photothermal properties, which could be controlled by the BP@SF content and near infrared (NIR) light power. The temperature of SF/PLGA/BP@SF composite membrane was increased by 15.26 °C under NIR (808 nm, 2.5 W/cm2) irradiation for 10 min. The photothermal property of SF/PLGA/BP@SF membranes significantly killed the HepG2 cancer cells in vitro, indicating its good potential for application in local treatment of cancer.
KW - black phosphorus nanosheets
KW - silk fibroin
KW - cancer
KW - photothermal therapy
KW - electrospinning
U2 - 10.3390/molecules27144563
DO - 10.3390/molecules27144563
M3 - Article
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 14
M1 - 4563
ER -
