Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck

J. K. Field; D. A. Spandidos; A. Malliri; J. R. Gosney; M. Yiagnisis; P. M. Stell

Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck

J. K. Field, D. A. Spandidos, A. Malliri, J. R. Gosney, M. Yiagnisis, P. M. Stell

Cancer Research UK Manchester Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously treated or not, nor any of the clinico-pathological parameters. However a correlation was found between the patients smoking history and positive p53 staining. Six out of seven non-smokers did not express p53 whereas 29 of 37 heavy smokers were found to have elevated p53 expression (P

Original language	English
Pages (from-to)	573-577
Number of pages	4
Journal	British Journal of Cancer
Volume	64
Issue number	3
Publication status	Published - 1991

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title = "Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck",

abstract = "Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously treated or not, nor any of the clinico-pathological parameters. However a correlation was found between the patients smoking history and positive p53 staining. Six out of seven non-smokers did not express p53 whereas 29 of 37 heavy smokers were found to have elevated p53 expression (P",

author = "Field, {J. K.} and Spandidos, {D. A.} and A. Malliri and Gosney, {J. R.} and M. Yiagnisis and Stell, {P. M.}",

year = "1991",

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T1 - Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck

AU - Field, J. K.

AU - Spandidos, D. A.

AU - Malliri, A.

AU - Gosney, J. R.

AU - Yiagnisis, M.

AU - Stell, P. M.

PY - 1991

Y1 - 1991

N2 - Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously treated or not, nor any of the clinico-pathological parameters. However a correlation was found between the patients smoking history and positive p53 staining. Six out of seven non-smokers did not express p53 whereas 29 of 37 heavy smokers were found to have elevated p53 expression (P

AB - Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously treated or not, nor any of the clinico-pathological parameters. However a correlation was found between the patients smoking history and positive p53 staining. Six out of seven non-smokers did not express p53 whereas 29 of 37 heavy smokers were found to have elevated p53 expression (P

M3 - Article

C2 - 1911200

SN - 0007-0920

VL - 64

SP - 573

EP - 577

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 3

ER -

Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck

Abstract

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