ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)

Steven D P Moore; Onyinye Offor; Judith A Ferry; Philip C Amrein; Cynthia C Morton; Paola Dal Cin

doi:10.1016/j.leukres.2005.10.014

ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)

Steven D P Moore, Onyinye Offor, Judith A Ferry, Philip C Amrein, Cynthia C Morton, Paola Dal Cin

Division of Evolution, Infection and Genomics

Brigham and Womens Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

We report a novel chromosomal translocation in AML, t(X;21)(q25-26;q22), resulting in a fusion transcript between two ETS domain family members, ELF4 (at Xq25) and ERG (at 21q22). ERG has been associated previously with other fusion partners, specifically FUS and EWSR1, and implicated in both AML and Ewing's sarcoma. RT-PCR analysis of RNA isolated from bone marrow samples from the patient demonstrates that the translocation occurs within intron 1 of ERG isoform 1 (ERG-1) and intron 2 of ELF4 resulting in an in-frame fusion joining exon 2 from ELF4 with exon 2 of ERG. This is the first reported case of an ELF4-ERG fusion and identification of the specific ERG exon involved in the fusion that differentiates ERG isoforms. In addition, this case also directly implicates a new role for ELF4 in cancer.

Original language	English
Pages (from-to)	1037-42
Number of pages	6
Journal	Leukemia Research
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.leukres.2005.10.014
Publication status	Published - Aug 2006

Keywords

Acute Disease
Chromosome Aberrations
Chromosome Mapping
Chromosomes, Human, Pair 21
Chromosomes, Human, X
DNA-Binding Proteins
Fatal Outcome
Female
Humans
In Situ Hybridization, Fluorescence
Leukemia, Myeloid
Middle Aged
Oncogene Proteins, Fusion
Reverse Transcriptase Polymerase Chain Reaction
Sensitivity and Specificity
Trans-Activators
Transcription Factors
Transcriptional Regulator ERG
Translocation, Genetic
Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.leukres.2005.10.014

Cite this

@article{b50c45646243450982f7eb352994d8ca,

title = "ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)",

abstract = "We report a novel chromosomal translocation in AML, t(X;21)(q25-26;q22), resulting in a fusion transcript between two ETS domain family members, ELF4 (at Xq25) and ERG (at 21q22). ERG has been associated previously with other fusion partners, specifically FUS and EWSR1, and implicated in both AML and Ewing's sarcoma. RT-PCR analysis of RNA isolated from bone marrow samples from the patient demonstrates that the translocation occurs within intron 1 of ERG isoform 1 (ERG-1) and intron 2 of ELF4 resulting in an in-frame fusion joining exon 2 from ELF4 with exon 2 of ERG. This is the first reported case of an ELF4-ERG fusion and identification of the specific ERG exon involved in the fusion that differentiates ERG isoforms. In addition, this case also directly implicates a new role for ELF4 in cancer.",

keywords = "Acute Disease, Chromosome Aberrations, Chromosome Mapping, Chromosomes, Human, Pair 21, Chromosomes, Human, X, DNA-Binding Proteins, Fatal Outcome, Female, Humans, In Situ Hybridization, Fluorescence, Leukemia, Myeloid, Middle Aged, Oncogene Proteins, Fusion, Reverse Transcriptase Polymerase Chain Reaction, Sensitivity and Specificity, Trans-Activators, Transcription Factors, Transcriptional Regulator ERG, Translocation, Genetic, Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",

author = "Moore, {Steven D P} and Onyinye Offor and Ferry, {Judith A} and Amrein, {Philip C} and Morton, {Cynthia C} and {Dal Cin}, Paola",

year = "2006",

month = aug,

doi = "10.1016/j.leukres.2005.10.014",

language = "English",

volume = "30",

pages = "1037--42",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier BV",

number = "8",

}

TY - JOUR

T1 - ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)

AU - Moore, Steven D P

AU - Offor, Onyinye

AU - Ferry, Judith A

AU - Amrein, Philip C

AU - Morton, Cynthia C

AU - Dal Cin, Paola

PY - 2006/8

Y1 - 2006/8

N2 - We report a novel chromosomal translocation in AML, t(X;21)(q25-26;q22), resulting in a fusion transcript between two ETS domain family members, ELF4 (at Xq25) and ERG (at 21q22). ERG has been associated previously with other fusion partners, specifically FUS and EWSR1, and implicated in both AML and Ewing's sarcoma. RT-PCR analysis of RNA isolated from bone marrow samples from the patient demonstrates that the translocation occurs within intron 1 of ERG isoform 1 (ERG-1) and intron 2 of ELF4 resulting in an in-frame fusion joining exon 2 from ELF4 with exon 2 of ERG. This is the first reported case of an ELF4-ERG fusion and identification of the specific ERG exon involved in the fusion that differentiates ERG isoforms. In addition, this case also directly implicates a new role for ELF4 in cancer.

AB - We report a novel chromosomal translocation in AML, t(X;21)(q25-26;q22), resulting in a fusion transcript between two ETS domain family members, ELF4 (at Xq25) and ERG (at 21q22). ERG has been associated previously with other fusion partners, specifically FUS and EWSR1, and implicated in both AML and Ewing's sarcoma. RT-PCR analysis of RNA isolated from bone marrow samples from the patient demonstrates that the translocation occurs within intron 1 of ERG isoform 1 (ERG-1) and intron 2 of ELF4 resulting in an in-frame fusion joining exon 2 from ELF4 with exon 2 of ERG. This is the first reported case of an ELF4-ERG fusion and identification of the specific ERG exon involved in the fusion that differentiates ERG isoforms. In addition, this case also directly implicates a new role for ELF4 in cancer.

KW - Acute Disease

KW - Chromosome Aberrations

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 21

KW - Chromosomes, Human, X

KW - DNA-Binding Proteins

KW - Fatal Outcome

KW - Female

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Leukemia, Myeloid

KW - Middle Aged

KW - Oncogene Proteins, Fusion

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Sensitivity and Specificity

KW - Trans-Activators

KW - Transcription Factors

KW - Transcriptional Regulator ERG

KW - Translocation, Genetic

KW - Case Reports

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.leukres.2005.10.014

DO - 10.1016/j.leukres.2005.10.014

M3 - Article

C2 - 16303180

SN - 0145-2126

VL - 30

SP - 1037

EP - 1042

JO - Leukemia Research

JF - Leukemia Research

IS - 8

ER -

ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this