Embryo Morphogenesis and the Role of the Actin Cytoskeleton

Sarah Woolner, Paul Martin

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    During embryogenesis, the tissues of the developing embryo must be bent, tugged, and sculpted in a series of morphogenetic episodes that flow from one to another to generate the final shape of the fetus. The mechanisms underlying these events share startling similarities across a great variety of animals. A primary component of morphogenesis is the actin cytoskeleton, which drives all of the cell shape changes, the tissue bending, and the fusion events that characterize embryogenesis. In this chapter we explore how regulation of the actin cytoskeleton contributes to morphogenetic episodes in worm, fly, fish, mouse, and chick embryos. In particular, we focus on how each of the different structures formed by actin function in morphogenesis and consider how recent research has expanded our knowledge of this area. © 2006 Elsevier Inc. All rights reserved.
    Original languageEnglish
    Title of host publicationAdvances in Molecular and Cell Biology|Adv. Mol. Cell Biol.
    Place of PublicationSan Diego, CA
    PublisherElsevier BV
    Pages251-283
    Number of pages32
    Volume37
    Edition37
    DOIs
    Publication statusPublished - 2006

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