Embryonic cerebrospinal fluid formation and regulation

David Bueno, Maryam Parvas, Mohammad Nabiuni, Jaleel Miyan

Research output: Contribution to journalArticlepeer-review


The vertebrate brain is organized, from its embryonic origin and throughout adult life, around a dynamic and complex fluid, the cerebrospinal fluid (CSF). There is growing interest in the composition, dynamics and function of the CSF in brain development research. It has been demonstrated in higher vertebrates that CSF has key functions in delivering diffusible signals and nutrients to the developing brain, contributing to the proliferation, differentiation and survival of neural progenitor cells, and to the patterning of the brain. It has also been shown that the composition and the homeostasis of CSF are tightly regulated following the closure of the anterior neuropore, just before the initiation of primary neurogenesis in the neural tissue surrounding brain cavities, before the formation of functional choroid plexus. In this review we draw together existing literature about the composition and formation of embryonic cerebrospinal fluid in birds and mammals, from the closure of the anterior neuropore to the formation of functional fetal choroid plexus, including mechanisms regulating its composition and homeostasis. The significance of CSF regulation within embryonic brain is also discussed from an evolutionary perspective.
Original languageEnglish
JournalSeminars in cell & developmental biology
Early online date12 Oct 2019
Publication statusPublished - 2019


  • Embryonic cerebrospinal fluid (eCSF)
  • blood–eCSF interface
  • eCSF composition
  • Brain development
  • Cephalic vesicles
  • Vertebrates


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