Embryonic stem cells: A novel source of dendritic cells for clinical applications

Paul J. Fairchild, Kathleen F. Nolan, Siân Cartland, Herman Waldmann

    Research output: Contribution to journalArticlepeer-review

    Abstract

    As arbitrators of the immune response, dendritic cells (DC) are uniquely placed to negotiate the balance between the opposing forces of tolerance and immunity, making them attractive candidates for clinical applications. Accordingly, DC have been used successfully in the treatment of cancer, enhancing immune responses to tumour-associated antigens (TAA) in experimental animal models and phase I clinical trials. A novel source of DC that has recently been described is the embryonic stem (ES) cell whose differentiation in vitro may be directed along multiple lineage pathways. Such pluripotency offers unparalleled opportunities for the treatment of chronic and degenerative disease states by the replacement of affected tissues, a vision which has inspired the emerging field of regenerative medicine. By sharing the genotype of therapeutic cell types, such as cardiomyocytes and dopaminergic neurons derived from the same ES cell line, so-called esDC may offer prospects for reprogramming the immune system to tolerate the grafted tissues. Here, we describe how the unique properties of esDC and the ES cells from which they derive, make them eminently suited to clinical applications, overcoming many of the issues that currently limit the effectiveness of DC-based immune intervention. © 2004 Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)13-21
    Number of pages8
    JournalInternational immunopharmacology
    Volume5
    Issue number1
    DOIs
    Publication statusPublished - Jan 2005

    Keywords

    • Dendritic cells
    • Embryonic stem cells
    • Regenerative medicine
    • Tolerance

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