TY - JOUR
T1 - Emergence of a multidrug-resistant (ASSuTTm) strain of salmonella enterica serovar typhimurium DT120 in England in 2011 and the use of multiple-locus variable-number tandem-repeat analysis in supporting outbreak investigations
AU - Paranthaman, Karthikeyan
AU - Haroon, Sophie
AU - Latif, Samia
AU - Vinnyey, Natalie
AU - De Souza, Valerie
AU - Welfare, William
AU - Tahir, Mamoona
AU - Cooke, Edward
AU - Stone, Kirsten
AU - Lane, Chris
AU - Peters, Tansy
AU - Puleston, Richard
PY - 2013/10/1
Y1 - 2013/10/1
N2 - In summer 2011, two outbreaks of a unique, multidrug-resistant strain of Salmonella enterica serovar Typhimurium phage type 120 (DT120) occurred mainly in the Midlands, England. The first outbreak occurred among guests attending a wedding in July 2011 ('Wedding outbreak'), followed by a more geographically dispersed outbreak in August and September 2011 ('Midlands outbreak'). Fifty-one cases were confirmed. Detailed epidemiological and environmental health investigations suggested that pork was the most likely source of both outbreaks. All human samples and one pork sample showed the specific multiple-locus variable-number tandem-repeat analysis (MLVA) profile 3-11-12-NA-0211, with at most two loci variations. Trace-back investigations suggested a link to a butcher's shop and a pig farm in the East Midlands. The investigations highlight the utility of molecular analysis (MLVA) in supporting epidemiological investigations of outbreaks caused by S. Typhimurium DT120. Safe handling and cooking of pork by food business operators and consumers are key interventions to prevent future outbreaks. © Copyright 2013, Mary Ann Liebert, Inc. 2013.
AB - In summer 2011, two outbreaks of a unique, multidrug-resistant strain of Salmonella enterica serovar Typhimurium phage type 120 (DT120) occurred mainly in the Midlands, England. The first outbreak occurred among guests attending a wedding in July 2011 ('Wedding outbreak'), followed by a more geographically dispersed outbreak in August and September 2011 ('Midlands outbreak'). Fifty-one cases were confirmed. Detailed epidemiological and environmental health investigations suggested that pork was the most likely source of both outbreaks. All human samples and one pork sample showed the specific multiple-locus variable-number tandem-repeat analysis (MLVA) profile 3-11-12-NA-0211, with at most two loci variations. Trace-back investigations suggested a link to a butcher's shop and a pig farm in the East Midlands. The investigations highlight the utility of molecular analysis (MLVA) in supporting epidemiological investigations of outbreaks caused by S. Typhimurium DT120. Safe handling and cooking of pork by food business operators and consumers are key interventions to prevent future outbreaks. © Copyright 2013, Mary Ann Liebert, Inc. 2013.
U2 - 10.1089/fpd.2013.1513
DO - 10.1089/fpd.2013.1513
M3 - Article
SN - 1535-3141
VL - 10
SP - 850
EP - 855
JO - Foodborne Pathogens and Disease
JF - Foodborne Pathogens and Disease
IS - 10
ER -
