Emergence of Echinocandin Resistance due to a Point Mutation in the fks1 Gene in a Patient with Chronic Pulmonary Aspergillosis

Cristina  Jiménez-Ortigosa; Caroline Moore; David Denning; David S. Perlin

doi:10.1128/AAC.01277-17

Emergence of Echinocandin Resistance due to a Point Mutation in the fks1 Gene in a Patient with Chronic Pulmonary Aspergillosis

Cristina Jiménez-Ortigosa, Caroline Moore, David Denning, David S. Perlin

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We have identified the first case of fks1 hot spot 1 point mutation causing echinocandin resistance in a clinical Aspergillus fumigatus isolate recovered from a patient with an aspergilloma and chronic pulmonary aspergillosis who first failed azole therapy and then was treated with micafungin.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Early online date	22 Nov 2017
DOIs	https://doi.org/10.1128/AAC.01277-17
Publication status	Published - Dec 2017

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10.1128/AAC.01277-17Licence: CC BY

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title = "Emergence of Echinocandin Resistance due to a Point Mutation in the fks1 Gene in a Patient with Chronic Pulmonary Aspergillosis",

abstract = "We have identified the first case of fks1 hot spot 1 point mutation causing echinocandin resistance in a clinical Aspergillus fumigatus isolate recovered from a patient with an aspergilloma and chronic pulmonary aspergillosis who first failed azole therapy and then was treated with micafungin.",

author = "Cristina Jim{\'e}nez-Ortigosa and Caroline Moore and David Denning and Perlin, {David S.}",

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AU - Jiménez-Ortigosa, Cristina

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AU - Denning, David

AU - Perlin, David S.

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AB - We have identified the first case of fks1 hot spot 1 point mutation causing echinocandin resistance in a clinical Aspergillus fumigatus isolate recovered from a patient with an aspergilloma and chronic pulmonary aspergillosis who first failed azole therapy and then was treated with micafungin.

UR - http://europepmc.org/abstract/med/28923871

U2 - 10.1128/AAC.01277-17

DO - 10.1128/AAC.01277-17

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SN - 0066-4804

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

ER -

Emergence of Echinocandin Resistance due to a Point Mutation in the fks1 Gene in a Patient with Chronic Pulmonary Aspergillosis

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