Emerging mechanisms for heavy metal transport in plants

Lorraine E. Williams, Jon K. Pittman, J. L. Hall

    Research output: Contribution to journalArticlepeer-review


    Heavy metal ions such as Cu2+, Zn2+, Mn2+, Fe2+, Ni2+ and Co2+ are essential micronutrients for plant metabolism but when present in excess, these, and non-essential metals such as Cd2+, Hg2+ and Pb2+, can become extremely toxic. Thus mechanisms must exist to satisfy the requirements of cellular metabolism but also to protect cells from toxic effects. The mechanisms deployed in the acquisition of essential heavy metal micronutrients have not been clearly defined although a number of genes have now been identified which encode potential transporters. This review concentrates on three classes of membrane transporters that have been implicated in the transport of heavy metals in a variety of organisms and could serve such a role in plants: the heavy metal (CPx-type) ATPases, the natural resistance-associated macrophage protein (Nramp) family and members of the cation diffusion facilitator (CDF) family. We aim to give an overview of the main features of these transporters in plants in terms of structure, function and regulation drawing on information from studies in a wide variety of organisms. Copyright (C) 2000 Elsevier Science B.V.
    Original languageEnglish
    Pages (from-to)104-126
    Number of pages22
    JournalBiochimica et Biophysica Acta - Biomembranes
    Issue number1-2
    Publication statusPublished - 1 May 2000


    • CDF family
    • CPx-ATPase
    • Membrane protein
    • Nramp


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