Emerging opportunities for the combination of molecularly targeted drugs with radiotherapy

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    Recent drug discovery developments in the field of small molecule targeted agents have led to much interest in combining these with radiotherapy. There are good preclinical data to suggest this approach worthy of investigation and in this review we discuss how this has translated into recent clinical trials. The outcome of clinical trials investigating radiotherapy/targeted drug combinations published in the last 5 years is discussed, as are trials in progress. The perceived future opportunities and challenges in the development of this exciting area are considered.
    Original languageEnglish
    Pages (from-to)266-276
    Number of pages10
    JournalClinical oncology (Royal College of Radiologists (Great Britain))
    Volume26
    Issue number5
    DOIs
    Publication statusPublished - May 2014

    Keywords

    • Molecularly targeted drugs
    • radiation
    • radiosensitisers
    • radiotherapy

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