Emerging opportunities for the combination of molecularly targeted drugs with radiotherapy

Emma Searle; T M Illidge; I J Stratford

doi:10.1016/j.clon.2014.02.006

Emerging opportunities for the combination of molecularly targeted drugs with radiotherapy

Research output: Contribution to journal › Review article › peer-review

Abstract

Recent drug discovery developments in the field of small molecule targeted agents have led to much interest in combining these with radiotherapy. There are good preclinical data to suggest this approach worthy of investigation and in this review we discuss how this has translated into recent clinical trials. The outcome of clinical trials investigating radiotherapy/targeted drug combinations published in the last 5 years is discussed, as are trials in progress. The perceived future opportunities and challenges in the development of this exciting area are considered.

Original language	English
Pages (from-to)	266-276
Number of pages	10
Journal	Clinical oncology (Royal College of Radiologists (Great Britain))
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/j.clon.2014.02.006 https://doi.org/10.1016/j.clon.2014.02.006
Publication status	Published - May 2014

Keywords

Molecularly targeted drugs
radiation
radiosensitisers
radiotherapy

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title = "Emerging opportunities for the combination of molecularly targeted drugs with radiotherapy",

abstract = "Recent drug discovery developments in the field of small molecule targeted agents have led to much interest in combining these with radiotherapy. There are good preclinical data to suggest this approach worthy of investigation and in this review we discuss how this has translated into recent clinical trials. The outcome of clinical trials investigating radiotherapy/targeted drug combinations published in the last 5 years is discussed, as are trials in progress. The perceived future opportunities and challenges in the development of this exciting area are considered.",

keywords = "Molecularly targeted drugs, radiation, radiosensitisers, radiotherapy",

author = "Emma Searle and Illidge, {T M} and Stratford, {I J}",

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PY - 2014/5

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AB - Recent drug discovery developments in the field of small molecule targeted agents have led to much interest in combining these with radiotherapy. There are good preclinical data to suggest this approach worthy of investigation and in this review we discuss how this has translated into recent clinical trials. The outcome of clinical trials investigating radiotherapy/targeted drug combinations published in the last 5 years is discussed, as are trials in progress. The perceived future opportunities and challenges in the development of this exciting area are considered.

KW - Molecularly targeted drugs

KW - radiation

KW - radiosensitisers

KW - radiotherapy

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DO - 10.1016/j.clon.2014.02.006

M3 - Review article

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ER -

Emerging opportunities for the combination of molecularly targeted drugs with radiotherapy

Abstract

Keywords

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