TY - JOUR
T1 - Enantio- and Diastereoselective Synthesis of Homopropargyl Amines by Copper-Catalyzed Coupling of Imines, 1,3-Enynes, and Diborons
AU - Manna, Srimanta
AU - Dherbassy, Quentin
AU - Perry, Gregory J. P.
AU - Procter, David John
PY - 2020
Y1 - 2020
N2 - An efficient, enantio‐ and diastereoselective, copper‐catalyzed coupling of imines, 1,3‐enynes, and diborons is reported. The process shows broad substrate scope and delivers complex, chiral homopropargyl amines; useful building blocks en route to biologically‐relevant compounds. In particular, functionalized homopropargyl amines bearing up to three contiguous stereocenters can be prepared in a single step.
AB - An efficient, enantio‐ and diastereoselective, copper‐catalyzed coupling of imines, 1,3‐enynes, and diborons is reported. The process shows broad substrate scope and delivers complex, chiral homopropargyl amines; useful building blocks en route to biologically‐relevant compounds. In particular, functionalized homopropargyl amines bearing up to three contiguous stereocenters can be prepared in a single step.
KW - copper
KW - borylative coupling
KW - homopropargyl amines
KW - 1, 3-enynes
KW - asymmetric catalysis
UR - https://www.scopus.com/pages/publications/85079387624
U2 - 10.1002/anie.201915191
DO - 10.1002/anie.201915191
M3 - Article
SN - 1433-7851
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
ER -