Enantioselective and Regioselective Copper-Catalyzed Borocyanation of 1-Aryl-1,3-Butadienes

Tao Jia, Marshall J. Smith, Alexander P. Pulis, Gregory J. P. Perry, David J. Procter

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    Abstract

    A multicomponent copper-catalyzed enantio- and regioselective borocyanation of 1-aryl-1,3-butadienes has been developed. The method provides access to functionalized allylic nitriles in up to 90% yield and 94% ee and thus overcomes some of the long-standing problems associated with the enantioselective insertion of cyano groups into unsaturated organic molecules. Both boron and cyano functionalities can be used as handles for selective manipulation.
    Original languageEnglish
    Pages (from-to)6744-6750
    JournalACS Catalysis
    Early online date28 Jun 2019
    DOIs
    Publication statusPublished - 2019

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