Endocytic transport of integrins during cell migration and invasion

Patrick Caswell, Jim Norman

    Research output: Contribution to journalArticlepeer-review


    Early studies describing the endocytic-exocytic cycling of integrins prompted proposals that this process regulates cell migration. However, it is only relatively recently that more detailed descriptions of the molecular machinery responsible for directing integrin trafficking have enabled us to properly address the role of these events during the various modes of cell migration. Here, we review recent advances in our understanding of the protein complexes and signallosomes controlling integrin trafficking, and we describe how these influence cell migration and signalling events downstream of integrin engagement. Furthermore, we consider recent evidence for integrin trafficking during the invasive migration of cancer cells through 3D microenvironments, and conclude with a discussion of the use of novel photoactivatable integrin probes to visualize these processes. © 2008 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)257-263
    Number of pages6
    JournalTrends in cell biology
    Issue number6
    Publication statusPublished - Jun 2008


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