Endogenous allergens and compositional analysis in the allergenicity assessment of genetically modified plants

A. Fernandez, E. N C Mills, M. Lovik, A. Spoek, A. Germini, A. Mikalsen, J. M. Wal

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Allergenicity assessment of genetically modified (GM) plants is one of the key pillars in the safety assessment process of these products. As part of this evaluation, one of the concerns is to assess that unintended effects (e.g. over-expression of endogenous allergens) relevant for the food safety have not occurred due to the genetic modification. Novel technologies are now available and could be used as complementary and/or alternative methods to those based on human sera for the assessment of endogenous allergenicity. In view of these developments and as a step forward in the allergenicity assessment of GM plants, it is recommended that known endogenous allergens are included in the compositional analysis as additional parameters to be measured. © 2013 Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)1-6
    Number of pages5
    JournalFood and Chemical Toxicology
    Volume62
    DOIs
    Publication statusPublished - Dec 2013

    Keywords

    • Allergenicity assessment
    • Comparative analysis
    • Endogenous allergens
    • Food and feed
    • Genetically modified organism

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