Endogenous factors controlling sleep

B. J. Pollard; P. B. Haywood; C. J D Pomfrett

doi:10.1054/cacc.2002.0377

Endogenous factors controlling sleep

B. J. Pollard, P. B. Haywood, C. J D Pomfrett

Research output: Contribution to journal › Article › peer-review

Abstract

Interest has been directed towards natural substances utilizing the same mechanisms employed by hypnotic anaesthetic agents. A number of endogenous substances exist which can be described as controllers of sleep and arousal. Amongst these are oleamide, linoleamide, anandamide, delta-sleep-inducing peptide (DSIP), vasoactive intestinal peptide and cholecystokinin. Oleamide has been shown to accumulate in sleep deprivation, and to induce sleep when injected into normal animals. This action appears to be mediated via 5HT2 and 5HT7 receptors and possibly GABAA receptors where it functions as a modulator of transmission, not an agonist. Delta-sleep-inducing peptide is found in CSF, plasma, urine and milk and is a nonapeptide which promotes sleep. Analogues of DSIP also exist which are either sleep promoting or sleep inhibiting. DSIP has been used for the treatment of insomnia and drug dependence with limited success, but not as an adjunct to anaesthesia. © 2002 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	16-22
Number of pages	6
Journal	Current Anaesthesia and Critical Care
Volume	13
Issue number	1
DOIs	https://doi.org/10.1054/cacc.2002.0377
Publication status	Published - 2002

Keywords

Amides
Circadian rhythm
Delta-sleep-inducing peptide
Oleic acid
Peptides
Sleep
Sleep deprivation
Vasoactive intestinal peptide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1054/cacc.2002.0377

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title = "Endogenous factors controlling sleep",

abstract = "Interest has been directed towards natural substances utilizing the same mechanisms employed by hypnotic anaesthetic agents. A number of endogenous substances exist which can be described as controllers of sleep and arousal. Amongst these are oleamide, linoleamide, anandamide, delta-sleep-inducing peptide (DSIP), vasoactive intestinal peptide and cholecystokinin. Oleamide has been shown to accumulate in sleep deprivation, and to induce sleep when injected into normal animals. This action appears to be mediated via 5HT2 and 5HT7 receptors and possibly GABAA receptors where it functions as a modulator of transmission, not an agonist. Delta-sleep-inducing peptide is found in CSF, plasma, urine and milk and is a nonapeptide which promotes sleep. Analogues of DSIP also exist which are either sleep promoting or sleep inhibiting. DSIP has been used for the treatment of insomnia and drug dependence with limited success, but not as an adjunct to anaesthesia. {\textcopyright} 2002 Elsevier Science Ltd. All rights reserved.",

keywords = "Amides, Circadian rhythm, Delta-sleep-inducing peptide, Oleic acid, Peptides, Sleep, Sleep deprivation, Vasoactive intestinal peptide",

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year = "2002",

doi = "10.1054/cacc.2002.0377",

language = "English",

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KW - Amides

KW - Circadian rhythm

KW - Delta-sleep-inducing peptide

KW - Oleic acid

KW - Peptides

KW - Sleep

KW - Sleep deprivation

KW - Vasoactive intestinal peptide

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DO - 10.1054/cacc.2002.0377

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SN - 0953-7112

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JO - Current Anaesthesia and Critical Care

JF - Current Anaesthesia and Critical Care

IS - 1

ER -

Endogenous factors controlling sleep

Abstract

Keywords

UN SDGs

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