TY - JOUR
T1 - Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: Results from the European Male Ageing Study
AU - Lee, David M.
AU - Ulubaev, Aslan
AU - Tajar, Abdelouahid
AU - Pye, Stephen R.
AU - Pendleton, Neil
AU - Purandare, Nitin
AU - O'Neill, Terence W.
AU - O'Connor, Daryl B.
AU - Labrie, Fernand
AU - Platt, Hazel
AU - Payne, Debbie
AU - Bartfai, Gyorgy
AU - Boonen, Steven
AU - Casanueva, Felipe F.
AU - Finn, Joseph D.
AU - Forti, Gianni
AU - Giwercman, Aleksander
AU - Han, Thang S.
AU - Huhtaniemi, Ilpo T.
AU - Kula, Krzysztof
AU - Lean, Michael E J
AU - Punab, Margus
AU - Silman, Alan J.
AU - Vanderschueren, Dirk
AU - Wu, Frederick C W
AU - Petrone, Luisa
AU - Cilotti, Antonio
AU - Borghs, Herman
AU - Slowikowska-Hilczer, Jolanta
AU - Walczak-Jedrzejowska, Renata
AU - Steer, Philip
AU - Lage, Mary
AU - Földesi, Imre
AU - Fejes, Imre
AU - Korrovitz, Paul
AU - Jiang, Min
PY - 2010/6/1
Y1 - 2010/6/1
N2 - Objective: Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function.We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men. Design: Community-based, cross-sectional study of 3369 men aged 40-79 years. Methods: Cognition tests were the Rey-Osterrieth Complex Figure, Camden Topographical Recognition Memory and Digit-Symbol Substitution. A fluid cognition (FC) z-score was computed from the individual tests. Testosterone, oestradiol (OE2) and 5α-dihydrotestosterone were measured by gas chromatography-mass spectrometry; DHEAS, LH, FSH and sex hormone-binding globulin (SHBG) by electrochemiluminescence. Free testosterone and OE2 were calculated from total hormone, SHBG and albumin. CAG repeat lengths were assayed by PCR genotyping. Results: Total testosterone and free testosterone were associated with higher FC z-scores, LH and FSH with lower FC z-scores in age-adjusted linear regressions. After adjusting for health, lifestyle and centre, a modest association was only observed between DHEAS and a lower FC z-score (β=-0.011, P=0.02), although this was driven by subjects with DHEAS levels > 10 mmol/l. Locally weighted plots revealed no threshold effects between hormones and FC. There was no association between CAG repeat length and FC z-score after adjustment for age and centre (β=-0.007, P=0.06), nor any interaction effect between CAG repeat length and hormones. Conclusion: Our results suggest that endogenous hormones are not associated with a vision-based measure of FC among healthy, community-dwelling men. Further studies are warranted to determine whether 'high' DHEAS levels are associated with poorer performance on a broader range of neuropsychological tests. © 2010 European Society of Endocrinology.
AB - Objective: Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function.We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men. Design: Community-based, cross-sectional study of 3369 men aged 40-79 years. Methods: Cognition tests were the Rey-Osterrieth Complex Figure, Camden Topographical Recognition Memory and Digit-Symbol Substitution. A fluid cognition (FC) z-score was computed from the individual tests. Testosterone, oestradiol (OE2) and 5α-dihydrotestosterone were measured by gas chromatography-mass spectrometry; DHEAS, LH, FSH and sex hormone-binding globulin (SHBG) by electrochemiluminescence. Free testosterone and OE2 were calculated from total hormone, SHBG and albumin. CAG repeat lengths were assayed by PCR genotyping. Results: Total testosterone and free testosterone were associated with higher FC z-scores, LH and FSH with lower FC z-scores in age-adjusted linear regressions. After adjusting for health, lifestyle and centre, a modest association was only observed between DHEAS and a lower FC z-score (β=-0.011, P=0.02), although this was driven by subjects with DHEAS levels > 10 mmol/l. Locally weighted plots revealed no threshold effects between hormones and FC. There was no association between CAG repeat length and FC z-score after adjustment for age and centre (β=-0.007, P=0.06), nor any interaction effect between CAG repeat length and hormones. Conclusion: Our results suggest that endogenous hormones are not associated with a vision-based measure of FC among healthy, community-dwelling men. Further studies are warranted to determine whether 'high' DHEAS levels are associated with poorer performance on a broader range of neuropsychological tests. © 2010 European Society of Endocrinology.
U2 - 10.1530/EJE-09-0970
DO - 10.1530/EJE-09-0970
M3 - Article
C2 - 20231367
SN - 0804-4643
VL - 162
SP - 1155
EP - 1164
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - 6
ER -