Endogenous inhibition of experimentally induced cough in healthy subjects

E. C. Young; L. A. Houghton; K. J. Holt; A. A. Woodcock; J. A. Smith

doi:10.1136/thoraxjnl-2011-201054b.144a

Endogenous inhibition of experimentally induced cough in healthy subjects

E. C. Young, L. A. Houghton, K. J. Holt, A. A. Woodcock, J. A. Smith

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background The pathophysiology of chronic cough may include peripheral/central sensitisation of afferent pathways and/or a failure of inhibitory pathways. Cough can be voluntarily suppressed in healthy subjects, but the role of endogenous inhibition is unknown. Endogenous inhibitory pain pathways can be activated by applying a painful conditioning stimulus to one body part, to inhibit pain elsewhere, described as “Diffuse Noxious Inhibitory Controls”.

Aim To investigate if a painful conditioning stimulus applied to the hand would inhibit cough in healthy subjects.

Original language	Undefined
Journal	Thorax
DOIs	https://doi.org/10.1136/thoraxjnl-2011-201054b.144a
Publication status	Published - 2011

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10.1136/thoraxjnl-2011-201054b.144a

Cite this

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title = "Endogenous inhibition of experimentally induced cough in healthy subjects",

abstract = "Background The pathophysiology of chronic cough may include peripheral/central sensitisation of afferent pathways and/or a failure of inhibitory pathways. Cough can be voluntarily suppressed in healthy subjects, but the role of endogenous inhibition is unknown. Endogenous inhibitory pain pathways can be activated by applying a painful conditioning stimulus to one body part, to inhibit pain elsewhere, described as “Diffuse Noxious Inhibitory Controls”.Aim To investigate if a painful conditioning stimulus applied to the hand would inhibit cough in healthy subjects.",

author = "Young, {E. C.} and Houghton, {L. A.} and Holt, {K. J.} and Woodcock, {A. A.} and Smith, {J. A.}",

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AU - Holt, K. J.

AU - Woodcock, A. A.

AU - Smith, J. A.

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N2 - Background The pathophysiology of chronic cough may include peripheral/central sensitisation of afferent pathways and/or a failure of inhibitory pathways. Cough can be voluntarily suppressed in healthy subjects, but the role of endogenous inhibition is unknown. Endogenous inhibitory pain pathways can be activated by applying a painful conditioning stimulus to one body part, to inhibit pain elsewhere, described as “Diffuse Noxious Inhibitory Controls”.Aim To investigate if a painful conditioning stimulus applied to the hand would inhibit cough in healthy subjects.

AB - Background The pathophysiology of chronic cough may include peripheral/central sensitisation of afferent pathways and/or a failure of inhibitory pathways. Cough can be voluntarily suppressed in healthy subjects, but the role of endogenous inhibition is unknown. Endogenous inhibitory pain pathways can be activated by applying a painful conditioning stimulus to one body part, to inhibit pain elsewhere, described as “Diffuse Noxious Inhibitory Controls”.Aim To investigate if a painful conditioning stimulus applied to the hand would inhibit cough in healthy subjects.

U2 - 10.1136/thoraxjnl-2011-201054b.144a

DO - 10.1136/thoraxjnl-2011-201054b.144a

M3 - Article

SN - 0040-6376

JO - Thorax

JF - Thorax

ER -