Abstract
Objectives: To study endometrial differentiation in the peri-implantation phase of women with recurrent miscarriage and to compare the results with endometrium of normal fertile women. Design: A prospective study of endometrial specimens precisely timed from the LH surge, using traditional histologic dating (Noyes' criteria), quantitative histologic measurement (morphometric analysis), and immunohistochemical techniques. Results: Fifteen of 25 (60%) subjects in the recurrent miscarriage group had retarded endometrial development in the peri-implantation period as monitored by morphometry. The recurrent miscarriage group showed reduced levels of four mucin-related secretory epitopes, and greater reductions were associated with morphological retardation. Normal differentiation was observed in all of the 14 subjects in the control group. Conclusions: Women with idiopathic recurrent pregnancy loss may be divided into two distinct subgroups on the basis of their endometrial response in the peri-implantation period. Precisely timed endometrial biopsy should be incorporated in the investigation of recurrent miscarriage.
| Original language | English |
|---|---|
| Pages (from-to) | 989-996 |
| Number of pages | 7 |
| Journal | Fertility and Sterility |
| Volume | 62 |
| Issue number | 5 |
| Publication status | Published - 1994 |
Keywords
- Endometrium
- immunohistochemistry
- keratan sulphate
- morphometry
- MUC1
- mucin
- recurrent abortion
