Abstract
One of the most crucial aspects of Ca2+ signalling is the ability to generate highly localised transient elevations of the cytosolic Ca2+ concentration at specific strategically important target sites. Inevitably this necessitates a relatively high Ca2+ buffering power of the cytoplasm, which in turn makes movement of Ca2+ from one part of a cell to another difficult. Nature has evolved an elegant solution to this problem by creating operational Ca2+ tunnels through the endoplasmic reticulum. Very recently direct evidence that such tunnelling also occurs in neurons has been provided. © 2007 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 373-378 |
Number of pages | 5 |
Journal | Cell calcium |
Volume | 42 |
Issue number | 4-5 |
DOIs | |
Publication status | Published - Oct 2007 |
Keywords
- Ca2+ release
- Ca2+ signalling
- Ca2+ tunnel
- Endoplasmic reticulum
- Neurones
- Secretory cells