Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells

Ole H. Petersen, Alexei Verkhratsky

    Research output: Contribution to journalArticlepeer-review


    One of the most crucial aspects of Ca2+ signalling is the ability to generate highly localised transient elevations of the cytosolic Ca2+ concentration at specific strategically important target sites. Inevitably this necessitates a relatively high Ca2+ buffering power of the cytoplasm, which in turn makes movement of Ca2+ from one part of a cell to another difficult. Nature has evolved an elegant solution to this problem by creating operational Ca2+ tunnels through the endoplasmic reticulum. Very recently direct evidence that such tunnelling also occurs in neurons has been provided. © 2007 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)373-378
    Number of pages5
    JournalCell calcium
    Issue number4-5
    Publication statusPublished - Oct 2007


    • Ca2+ release
    • Ca2+ signalling
    • Ca2+ tunnel
    • Endoplasmic reticulum
    • Neurones
    • Secretory cells


    Dive into the research topics of 'Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells'. Together they form a unique fingerprint.

    Cite this