TY - JOUR
T1 - Endoscopic third ventriculostomy: Predicting outcome with phase-contrast MR imaging
AU - Stivaros, Stavros M.
AU - Sinclair, Deborah
AU - Bromiley, Paul A.
AU - Kim, Jieun
AU - Thorne, John
AU - Jackson, Alan
PY - 2009/9
Y1 - 2009/9
N2 - Purpose: To determine whether phase-contrast magnetic resonance (MR) imaging measurements of preoperative cerebral blood and cerebrospinal fluid (CSF) hydrodynamics can be used as a biomarker of response to endoscopic third ventriculostomy (ETV). Materials and Methods: Approval from the local research ethics committee and written informed consent were obtained for this prospective study. Thirteen patients (six female patients, seven male patients; median age, 43 years) with chronic obstructive hydrocephalus, 12 of whom went on to undergo ETV, were imaged with phase-contrast MR imaging at 1.5 T to determine rates of total cerebral blood flow (CBF) and ventriculostomy defect, foramen magnum (FM), and cerebral aqueduct CSF flow. Ten control subjects (10 men; median age, 37 years) were similarly imaged. Correlations between measured values were assessed by means of Pearson correlation coefficients. Measurements were compared between groups with a Mann-Whitney test, and measurements before and after surgical intervention were compared with a Wilcoxon test for paired samples. Results: Rates of CBF (356 mL·min-1 ± 73 [standard deviation] vs 518 mL·min-1 ± 79, P <.001) and CSF flow in the FM (17.62 mL·min-1 ± 13.12 vs 36.35 mL·min-1 ± 8, P <.05) were significantly lower in patients than in control subjects. Conclusion: ETV induces changes in brain volume and CBF that can be predicted by using simple metrics. These pilot results support a formal trial of these techniques in a larger prospective study. © RSNA, 2009.
AB - Purpose: To determine whether phase-contrast magnetic resonance (MR) imaging measurements of preoperative cerebral blood and cerebrospinal fluid (CSF) hydrodynamics can be used as a biomarker of response to endoscopic third ventriculostomy (ETV). Materials and Methods: Approval from the local research ethics committee and written informed consent were obtained for this prospective study. Thirteen patients (six female patients, seven male patients; median age, 43 years) with chronic obstructive hydrocephalus, 12 of whom went on to undergo ETV, were imaged with phase-contrast MR imaging at 1.5 T to determine rates of total cerebral blood flow (CBF) and ventriculostomy defect, foramen magnum (FM), and cerebral aqueduct CSF flow. Ten control subjects (10 men; median age, 37 years) were similarly imaged. Correlations between measured values were assessed by means of Pearson correlation coefficients. Measurements were compared between groups with a Mann-Whitney test, and measurements before and after surgical intervention were compared with a Wilcoxon test for paired samples. Results: Rates of CBF (356 mL·min-1 ± 73 [standard deviation] vs 518 mL·min-1 ± 79, P <.001) and CSF flow in the FM (17.62 mL·min-1 ± 13.12 vs 36.35 mL·min-1 ± 8, P <.05) were significantly lower in patients than in control subjects. Conclusion: ETV induces changes in brain volume and CBF that can be predicted by using simple metrics. These pilot results support a formal trial of these techniques in a larger prospective study. © RSNA, 2009.
U2 - 10.1148/radiol.2523081398
DO - 10.1148/radiol.2523081398
M3 - Article
C2 - 19587307
SN - 0033-8419
VL - 252
SP - 825
EP - 832
JO - Radiology
JF - Radiology
IS - 3
ER -