Endothelial dysfunction in rheumatoid arthritis: Influence of HLA-DRB1 alleles

Miguel A. Gonzalez-Gay, Carlos Gonzalez-Juanatey, William E. Ollier

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Cardiovascular disease is the commonest cause of premature mortality in rheumatoid arthritis (RA) patients. Vascular endothelial injury is the primary event in atherosclerosis. It has been associated with endothelial dysfunction. We have recently observed that actively treated RA patients had endothelial dysfunction. HLA-DRB1 shared epitope alleles, in particular HLA-DRB1*0404, seem to be implicated in the development of endothelial dysfunction. These results underline the influence of genetic factors in the risk of atherosclerosis in RA patients. © 2003 Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)301-304
    Number of pages3
    JournalAutoimmunity Reviews
    Volume3
    Issue number4
    DOIs
    Publication statusPublished - Jun 2004

    Keywords

    • Atherosclerosis
    • Endothelial dysfunction
    • Endothelium-dependent vasodilatation
    • HLA-DRB1 alleles
    • Rheumatoid arthritis
    • Shared epitope

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