Endothelial function and atrial fibrillation: A missing piece of the puzzle?

Nicholas Black, Fahad Mohammad, Karan Saraf, Gwilym Morris

Research output: Contribution to journalReview articlepeer-review


Endothelial dysfunction, a term used to describe both the physical damage and dysregulated physiology of this endothelial lining, is an increasingly recognized pathophysiological state shared by many cardiovascular diseases. Historically, the role of endothelial dysfunction in atrial fibrillation (AF) was thought to be limited to mediating atrial thromboembolism. However, there is emerging evidence that endothelial dysfunction both promotes and maintains atrial arrhythmic substrate, predicts adverse outcomes, and identifies patients at high risk of recurrence following cardioversion and ablation therapy. Treatments targeted at improving endothelial function also represent a promising new therapeutic paradigm in AF. This review summarizes the current understanding of endothelial function in AF.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalJournal of cardiovascular electrophysiology
Issue number1
Early online date9 Nov 2021
Publication statusPublished - Jan 2022


Dive into the research topics of 'Endothelial function and atrial fibrillation: A missing piece of the puzzle?'. Together they form a unique fingerprint.

Cite this