Endotoxin in blood and tissue in the sudden infant death syndrome

B. A. Crawley, J. A. Morris, D. B. Drucker, A. J. Barson, J. Morris, W. F. Knox, B. A. Oppenheim

    Research output: Contribution to journalArticlepeer-review


    Although the explanation for sudden infant death syndrome (SIDS) remains unknown, an increasing body of evidence now exists to suggest a possible role for bacterial toxins in the aetiology, and a number of investigators have considered that endotoxaemia could explain some of the associated features. Following the development of an animal model which confirmed that endotoxaemia could be detected after death, we studied endotoxin levels in blood and tissue samples taken at autopsy from SIDS infants, child controls and adult controls. There were significant correlations between endotoxin levels in blood and the various organs sampled particularly in SIDS cases and child controls, and blood endotoxin levels in SIDS cases were higher in those infants where there was histological evidence of mild to moderate inflammation. However, overall no significant differences were found between endotoxin levels in blood or tissue in the three study groups. Further studies into possible actions or interactions of endotoxin in SIDS are required. Copyright (C) 1999 Federation of European Microbiological Societies.
    Original languageEnglish
    Pages (from-to)131-135
    Number of pages4
    JournalFEMS Immunology and Medical Microbiology
    Issue number1-2
    Publication statusPublished - 1 Aug 1999


    • Endotoxin
    • Sudden infant death syndrome


    Dive into the research topics of 'Endotoxin in blood and tissue in the sudden infant death syndrome'. Together they form a unique fingerprint.

    Cite this